Soft Materials,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 8
Published: Nov. 24, 2024
In
this
research,
the
hydrogel
nanocomposites
based
on
acryl
amide
containing
penicillin
800,
1200,
Ag,
and
ZnO
nanoparticles
as
wound
dressing
applications
have
been
studied.
work,
preparation
was
done
via
a
reaction
of
optimal
values
to
produce
an
antibacterial
nanocomposite.
The
obtained
in
aqueous
medium
by
using
reagents
such
acrylamide,
potassium
persulfate,
methylene
bisacrylamide
crosslinker,
nanoparticles,
penicillins
then,
products
were
dried
white
powders.
properties
swelling
rate,
pH
sensitivity,
high
water
capacity
rate
study
showed
absorption
about
3–4.
effect
temperature
percentage
shown
swell
with
increasing
polyacrylamide
hydrogels
decreased
NaCl
concentration.
chemical
structure
confirmed
FTIR
spectrum,
morphology
synthesized
surfaces
studied
SEM.
studies
blood,
agar,
chocolate,
Müller
three
methods,
first
gram-negative
bacteria
E.
coli
Klebsiella,
second
urine
medium,
third
drug
medium.
This
polymeric
blend
can
be
used
new
compound.
Particulate Science And Technology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 17
Published: Feb. 13, 2025
Pullulan,
a
natural
polysaccharide
with
unique
biocompatibility
and
biodegradability,
has
gained
prominence
in
nanomedicine.
The
demand
for
the
development
of
environmentally
sustainable,
low-cost,
controlled-release
drug
delivery
systems
cancer
treatment
is
emerging.
Resveratrol
compound
that
anticancer
properties.
Targeted
direct
therapeutic
agents
specifically
to
cells
or
tumor
microenvironment,
minimizing
off-target
effects
improving
efficacy.
polymeric
nanoparticles
specific
properties
functionalities,
researchers
can
achieve
precise,
efficient,
controlled
delivery,
make
them
versatile
tool
site-specific
therapy
various
diseases.
This
study
focuses
on
developing
accessing
surface-functionalized
designed
targeted
an
agent,
resveratrol.
comprise
pullulan
polymer
are
ligand
n-acetyl
glucosamine
enhance
targeting
specificity.
Various
parameters
including
particle
size,
zeta
potential,
differential
scanning
calorimetry
(DSC),
FTIR,
field
emission
electron
microscopy
(FESEM),
transmission
(TEM),
x-ray
diffraction
(XRD),
entrapment
efficiency
(EE),
loading
analyzed
characterize
comprehensively.
In
vitro
evaluation
conducted
using
A549
cell
line,
cellular
uptake,
apoptosis,
cytotoxicity
evaluated
via
MTT
assay
determine
efficacy
delivering
resveratrol
cells.
Additionally,
vivo
utilizing
rat
model
pulmonary
route
performed
evaluate
pharmacokinetics
biodistribution
nanoparticles.
this
lie
their
ability
combine
biocompatibility,
release,
multifunctional
applications,
making
promising
platform
Overall,
research
provides
sustainable
offering
potential
advancements
therapy.
Cancer Cell International,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: May 25, 2025
Osteosarcoma
(OS),
chondrosarcoma
(CHS),
and
Ewing
sarcoma
(EWS)
are
the
main
types
of
bone
cancer
(BC).
OS
is
most
common
BC
in
this
group.
It
children
older
people,
especially
their
long
bones.
Treatments
for
sarcomas
tumors
have
slowly
improved,
so
researchers
began
looking
into
additional
alternative
approaches
to
standard
therapies.
Therefore,
ability
precisely
manipulate
metallic
nanoparticles
(MNPs)'
form,
size,
charge,
surface
modification
makes
them
very
useful
treating
cancer.
However,
due
biocompatibility
possible
toxicity
MNPs,
MNP
has
limits
clinical
use
BC.
green
synthesis
MNPs
achieved
by
bio-reducing
ions,
which
results
creation
NPs,
using
living
entities
or
extracts.
Green
derived
from
natural
sources
provide
a
secure
environmentally
responsible
solution.
Benefits
include
tailored
medicine
delivery
biocompatibility.
reduce
damage
healthy
cells
while
improving
targeting
cells.
In
study,
we
reviewed
how
different
synthesized
methods
can
help
treat
various
This
work
usual
way
making
BC,
problems
with
benefits
future
uses
synthetic
ACS Food Science & Technology,
Journal Year:
2024,
Volume and Issue:
4(12), P. 2998 - 3006
Published: Nov. 18, 2024
The
simple
and
green
pH-based
method
shows
promise
for
encapsulating
hydrophobic
molecules
in
delivery
systems
to
enhance
their
bioavailability.
However,
there
is
still
a
limited
understanding
of
the
pH-induced
structural
changes
that
are
involved.
In
this
study,
we
combine
experimental
techniques
with
molecular
dynamics
simulations
investigate
curcumin
crystals.
An
alkali-acid
pretreatment
was
introduced
encapsulate
curcumin,
where
first
dissolved
an
alkaline
solution
then
rapidly
acidified
form
aggregates.
Remarkably,
these
aggregates
can
be
spontaneously
encapsulated
into
emulsions,
even
at
high
concentrations
(1
mg/mL).
Microscopy
images
suggested
disrupts
crystalline
structure
curcumin.
Molecular
further
demonstrated
hydroxyl
groups
hydrogen
bonds
water
molecules,
while
interactions
dominate
within
pH-treated
increase
solvent-accessible
surface
area
promote
rapid
solubilization
emulsions
or
milks.
Abstract
5‐Fluorouracil
(5‐FU)
is
a
chemotherapeutic
agent
widely
used
to
treat
different
types
of
cancers.
However,
many
patients
present
with
obstacles
during
treatment
due
5‐FU
drug
resistance.
To
overcome
these
drawbacks,
novel
drug‐loaded
nanocarrier
(NC)
comprising
titanium
dioxide
(TiO
2
)
nanoparticles
surface
functionalized
facilitate
delivery
developed.
This
study
designs
and
evaluates
the
antitumour
effects
NCs
in
oral
cancer
(OC)
cell
lines
lymphoid
origin.
were
synthesized
by
biofunctionalization
TiO
3‐aminopropyl
triethoxysilane
(APTES)
which
was
then
loaded
5‐FU.
vitro
release
determined
at
three
pH
values.
The
effect
chemotherapy
studied
mono‐
co‐culture
systems
OC
cells
human
gingival
fibroblasts
(hGFs).
From
studies,
it
noted
that
after
24
h
an
acidic
medium
(pH
5.5),
more
than
80%
released
compared
basic
pH.
cytotoxicity
higher
when
combined
system
‐APTES,
comparison
alone
used.
NC
showed
increased
line
minimal
hGFs.
anticancer
/5‐FU
could
be
highly
effective
tumour
microenvironment.
Molecular Systems Design & Engineering,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
A
xanthan
gum-acrylamide
desiccant
with
interconnected
capillary
channels
was
prepared
and
showed
1.38
g
−1
water
adsorption
at
90%
RH
25
°C,
retaining
70%
capacity
over
20
cycles,
proving
its
effectiveness
as
a
salt-free
desiccant.
