Biomineralization Process Inspired In Situ Growth of Calcium Carbonate Nanocrystals in Chitosan Hydrogels DOI Creative Commons

Xinyue Zeng,

Zheng Zhu,

Wei Chang

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(20), P. 9193 - 9193

Published: Oct. 10, 2024

Biological composites such as bone, nacre, and teeth show excellent mechanical efficiency because of the incorporation biominerals into organic matrix at nanoscale, leading to hierarchical composite structures. Adding a large volume ceramic nanoparticles an molecular network uniformly has been challenge in engineering applications. However, natural organisms, grow inside fibers, chitin collagen, forming perfect ceramic/polymer spontaneously via biomineralization processes. Inspired from these processes, situ growth calcium carbonate chitosan form was proposed current work. The crystal CaCO3 function time investigated. A weight percentage ~35 wt% realized, resembling high mineral phase bones. Scanning transmission electron microscopy indicated integration nanocrystals with macromolecules. By growing minerals matrix, elastic modulus tensile strength increases by ~110% ~90%, respectively. strategy also demonstrated frameworks prepared 3D printing, indicating potential fabricating complicated structures, further applications tissue engineering.

Language: Английский

Integrating advanced synthesis techniques and AI-driven approaches with nanofiber technology: A state-of-the-art approach to wound care management DOI Creative Commons
Nisha Shankhwar, Awadhesh Kumar Verma, Ashab Noumani

et al.

Next Nanotechnology, Journal Year: 2025, Volume and Issue: 8, P. 100147 - 100147

Published: Jan. 1, 2025

Language: Английский

Citations

0
Bi-phasic integrated silk fibroin/polycaprolactone scaffolds for osteochondral regeneration inspired by the native joint tissue and interface DOI Creative Commons

Z Zhang,

Qingquan Dong,

Zubing Li

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101737 - 101737

Published: April 1, 2025

Osteochondral scaffolds designed with bi-phasic and multi-phasic have typically struggled post-implantation delamination. To address this issue, we developed a novel integrated scaffold natural continuous interface heterogeneous bilayer structure. Through layer-by-layer wet electrospinning, two-dimensional (2D) bi-layer membranes of silk fibroin (SF) polycaprolactone (PCL) were fabricated. These then transformed into three-dimensional (3D) using CO2 gas foaming technique, followed by gelatin coating on the osteogenic layer to afford final porous scaffolds. In vitro studies indicated that 3D better-maintained cell phenotypes than conventional 2D electrospun films. Additionally, showed superior cartilage repair osteoinductivity potential, increased subchondral bone volume reduced defect area in rat osteochondral defects models at 12 weeks. Taken together, these gas-foamed promising candidate for regeneration.

Language: Английский

Citations

0
3D Printing and Electrospinning of Drug- and Graphene-Enhanced Polycaprolactone Scaffolds for Osteochondral Nasal Repair DOI Open Access
Izabella Rajzer, Anna Kurowska, Anna Nikodem

et al.

Materials, Journal Year: 2025, Volume and Issue: 18(8), P. 1826 - 1826

Published: April 16, 2025

A novel bi-layered scaffold, obtained via 3D printing and electrospinning, was designed to improve osteochondral region reconstruction. The upper electrospun membrane will act as a barrier against unwanted tissue infiltration, while the lower 3D-printed layer provide porous structure for ingrowth. Graphene integrated into scaffold its antibacterial properties, drug Osteogenon® (OST) added promote bone regeneration. composite scaffolds were subjected comprehensive physical, thermal, mechanical evaluations. Additionally, their biological functionality assessed by means of NHAC-kn cells. 0.5% graphene addition PCL significantly increased strain at break, enhancing material ductility. GNP also acted an effective nucleating agent, raising crystallization temperatures supporting mineralization. high surface area facilitated rapid apatite formation attracting calcium phosphate ions. This confirmed FTIR, µCT SEM analyses, which highlighted positive impact on mineral deposition. synergistic interaction between nanoplatelets created bioactive environment that enhanced cell adhesion proliferation, promoted superior formation. These findings highlight scaffold’s potential promising biomaterial repair regenerative medicine.

Language: Английский

Citations

0
Electrospun Conductive Polymer Scaffolds: Tailoring Fiber Diameter and Electrical Properties for Tissue Engineering Applications DOI Creative Commons

Zary Adabavazeh,

Narges Johari, Francesco Baino

et al.

Materials Today Communications, Journal Year: 2025, Volume and Issue: unknown, P. 112596 - 112596

Published: April 1, 2025

Language: Английский

Citations

0
Biomineralization Process Inspired In Situ Growth of Calcium Carbonate Nanocrystals in Chitosan Hydrogels DOI Creative Commons

Xinyue Zeng,

Zheng Zhu,

Wei Chang

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(20), P. 9193 - 9193

Published: Oct. 10, 2024

Biological composites such as bone, nacre, and teeth show excellent mechanical efficiency because of the incorporation biominerals into organic matrix at nanoscale, leading to hierarchical composite structures. Adding a large volume ceramic nanoparticles an molecular network uniformly has been challenge in engineering applications. However, natural organisms, grow inside fibers, chitin collagen, forming perfect ceramic/polymer spontaneously via biomineralization processes. Inspired from these processes, situ growth calcium carbonate chitosan form was proposed current work. The crystal CaCO3 function time investigated. A weight percentage ~35 wt% realized, resembling high mineral phase bones. Scanning transmission electron microscopy indicated integration nanocrystals with macromolecules. By growing minerals matrix, elastic modulus tensile strength increases by ~110% ~90%, respectively. strategy also demonstrated frameworks prepared 3D printing, indicating potential fabricating complicated structures, further applications tissue engineering.

Language: Английский

Citations

0