Selenium-Doped Copper Formate Nanozymes with Antisenescence and Oxidative Stress Reduction for Atherosclerosis Treatment

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Atherosclerosis, resulting from chronic inflammation of the arterial wall, serves as underlying cause multiple major cardiovascular diseases. Current anti-inflammatory therapies often exhibit limited and unsatisfactory efficacy. To address this, we have designed a selenium-doped copper formate (Cuf-Se) nanozyme for treatment atherosclerosis, which possesses superoxide dismutase (SOD) glutathione peroxidase (GPx)-like activities. The Cuf-Se can efficiently scavenge reactive oxygen species (ROS), inhibit cellular senescence, prevent formation foam cells. It acts on macrophages to reduce ROS levels lipid oxidation, thereby significantly inhibiting inflammation-related processes. Notably, while cell formation, also alleviates endothelial cells senescence. After intravenous administration, effectively inhibits atherosclerosis in mice through synergistic effects antisenescence antioxidant properties, reducing plaque area by approximately 5-fold. This study provides an effective strategy atherosclerosis.

Language: Английский

Significantly improved catalytic activity of copper nanocrystal by introducing Ti3C2TX and arginine and serine-functionalized graphene quantum dot for colorimetric detection of H2O2

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(4)

Published: March 13, 2025

Language: Английский