Novel delivery systems for phages and lysins in the topical management of wound infections: a narrative review DOI Creative Commons
Pan‐Chyr Yang, Jing Li,

MA Xiu-mei

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 27, 2025

Currently, multidrug-resistant (MDR) bacterial wound infections (WIs) are an extremely challenging clinical problem for physicians. Recently, compared to traditional single liquid delivery drugs, the study of five novel drug systems (i.e., hydrogel, liposomes, electrospun fibers, nanoparticles and nanoemulsion) phages their encoded lysins in WI management has become a hot topic. To assess current landscape these emerging technologies, we conducted comprehensive literature search across PubMed, Scopus Web Science up July 2024, using terms such as “phage,” “lysin,” “wound,” “hydrogel,” “liposomes,” “fibers,” “nanoparticles,” “nanoemulsion.” The criteria included original studies management. findings highlighted positive effects management, significantly reducing populations, accelerating healing at injury site. However, available on remains limited, particularly lysins. In conclusion, application showed great potential combating MDR WIs.

Language: Английский

Novel delivery systems for phages and lysins in the topical management of wound infections: a narrative review DOI Creative Commons
Pan‐Chyr Yang, Jing Li,

MA Xiu-mei

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 27, 2025

Currently, multidrug-resistant (MDR) bacterial wound infections (WIs) are an extremely challenging clinical problem for physicians. Recently, compared to traditional single liquid delivery drugs, the study of five novel drug systems (i.e., hydrogel, liposomes, electrospun fibers, nanoparticles and nanoemulsion) phages their encoded lysins in WI management has become a hot topic. To assess current landscape these emerging technologies, we conducted comprehensive literature search across PubMed, Scopus Web Science up July 2024, using terms such as “phage,” “lysin,” “wound,” “hydrogel,” “liposomes,” “fibers,” “nanoparticles,” “nanoemulsion.” The criteria included original studies management. findings highlighted positive effects management, significantly reducing populations, accelerating healing at injury site. However, available on remains limited, particularly lysins. In conclusion, application showed great potential combating MDR WIs.

Language: Английский

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