Structural Characterization and Immunomodulatory Activity of a New Oligosaccharide from Marine-Derived Penicillium Citrinum Scau-268 DOI

Zongzhen Wang,

Jun Liu,

Kuan Kou

et al.

Published: Jan. 1, 2025

In this report, we detail the discovery and characterization of a new oligosaccharide, PCO-1, extracted from culture broth marine fungus Penicillium citrinum SCAU-268. The molecular weight PCO-1 was accurately measured to be 1476 Da, its primary structure identified as α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp-(1,6)-α-D-Glcp-(1,6)-α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp. Our results demonstrate that markedly elevated secretion cytokines IL-6, IL-1β, TNF-α, nitric oxide (NO) in concentration-dependent fashion. Metabolomic studies suggest may act through LACC1 pathway, promoting conversion citrulline ornithine modulating immune responses. conclusion, our study has successfully elucidated fungal-derived oligosaccharide confirmed potent immunomodulatory activity.

Language: Английский

Structural Characterization and Immunomodulatory Activity of a New Oligosaccharide from Marine-Derived Penicillium Citrinum Scau-268 DOI

Zongzhen Wang,

Jun Liu,

Kuan Kou

et al.

Published: Jan. 1, 2025

In this report, we detail the discovery and characterization of a new oligosaccharide, PCO-1, extracted from culture broth marine fungus Penicillium citrinum SCAU-268. The molecular weight PCO-1 was accurately measured to be 1476 Da, its primary structure identified as α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp-(1,6)-α-D-Glcp-(1,6)-α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp. Our results demonstrate that markedly elevated secretion cytokines IL-6, IL-1β, TNF-α, nitric oxide (NO) in concentration-dependent fashion. Metabolomic studies suggest may act through LACC1 pathway, promoting conversion citrulline ornithine modulating immune responses. conclusion, our study has successfully elucidated fungal-derived oligosaccharide confirmed potent immunomodulatory activity.

Language: Английский

Citations

0