Pharmaceutics, Journal Year: 2024, Volume and Issue: 17(1), P. 18 - 18

Published: Dec. 26, 2024

Background/Objectives: This study aimed to evaluate the safety and efficacy of chitosan-based bioadhesive films for facilitating topical delivery curcumin in skin cancer treatment, addressing pharmacokinetic limitations associated with oral administration. Methods: The films, which incorporated curcumin, were formulated using varying proportions chitosan, polyvinyl alcohol, Poloxamer® 407, propylene glycol. These assessed stability, drug release, vitro permeation, cell viability (with without radiotherapy), irritation. Results: demonstrated physical stability preserved content at room temperature 90 days. Drug release was effectively controlled during first 8 h, rates ranging from 51.6 ± 4.8% 65.6 13.0%. also enhanced penetration into compared a solution used as control (stratum corneum: 1.3 0.1 1.9 0.8 µg/cm²; deeper layers: 1.7 2.7 0.2 µg/cm²). A cytotoxicity test on metastatic melanoma cells showed that doses exerted activity similar delivered via skin. Furthermore, alone more effective inhibiting tumor than radiotherapy (p < 0.01), no additional benefit observed when combined radiotherapy. Finally, irritation tests confirmed safe application. Conclusion: developed represent promising alternative treatment tumors curcumin.

Language: Английский