Dandelion-shaped strontium-gallium microparticles for the hierarchical stimulation and comprehensive regulation of wound healing DOI Creative Commons

Minrui Ji,

Zaixin Yuan,

Hongdong Ma

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract The management of full-thickness skin injuries continues to pose significant challenges. Currently, there is a dearth comprehensive dressings capable integrating all stages wound healing spatiotemporally regulate biological processes following injuries. In this study, we report the synthesis dandelion-shaped mesoporous strontium-gallium microparticle (GE@SrTPP) achieved through dopamine-mediated strontium ion biomineralization and self-assembly, followed by functionalization with gallium metal polyphenol networks. As multifunctional dressing, GE@SrTPP can release bioactive ions in spatiotemporal manner akin dandelion seeds. During early healing, demonstrates rapid effective hemostatic performance while also exhibiting antibacterial properties. inflammatory phase, promotes M2 polarization macrophages, suppresses expression pro-inflammatory factors, decreases oxidative stress wounds. Subsequently, during proliferation tissue remodeling, facilitates angiogenesis activation Hypoxia-inducible factor-1α/vascular endothelial growth factor (HIF-1α/VEGF) pathway. Analogous dispersion rooting seeds, root-like new blood vessels supply essential nutrients for healing. Ultimately, rat chronic model, successful repair. summary, these microparticles demonstrate regulatory effects managing wounds, making them highly promising materials clinical applications.

Language: Английский

Recent Advances, Research Trends, and Clinical Relevance of Hyaluronic Acid Applied to Wound Healing and Regeneration DOI Creative Commons
Gloria Huerta‐Ángeles, Edgar Mixcoha

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 536 - 536

Published: Jan. 9, 2025

Hyaluronan (HA) is a ubiquitous macromolecule in the human body with remarkable structure and function. HA presents key role several biological processes mammals. The synthesis/catabolism of critical pathologies has been used as marker for prognosis cancers. Among its physiological roles, wound healing applications. This review reports many latest developments hyaluronan derivatives research, preclinical, published clinical trials healing. An adequate physico-chemical characterization identification selected properties prepared material are mandatory. Moreover, cytotoxicity evaluation effects vitro using standardized protocols required preclinical. Finally, to choose vivo models testing efficacy requested. Unfortunately, still not well understood. Therefore, an overview HA-based products provided discussed. Several ways chemical modification were evaluated. this focuses on containing HA, novel developments, gaps, limitations current state art.

Language: Английский

Citations

1
Recent advances in hyaluronic acid-based hydrogels for diabetic wound healing DOI
Chenguang Liu,

Ronger Ai,

Bi-zhi Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140797 - 140797

Published: Feb. 7, 2025

Language: Английский

Citations

1
Metformin-Loaded Tannic Acid Nanoparticles Attenuate Osteoarthritis by Promoting Chondrocyte Mitochondria Homeostasis Based on Mitocytosis DOI
Wacili Da, Xiangtian Deng, Quan Chen

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

The oxidative stress microenvironment and mitochondrial dysfunction in chondrocytes are key mechanisms the development of osteoarthritis (OA). Metformin (Met) has demonstrated multiple effects on mitochondria is regarded as a potential therapeutic agent for OA. low blood flow characteristics joint cavity make targeted local delivery metformin crucial its clinical application. In this study, tannic acid (TA), with natural antioxidant anti-inflammatory properties, was used to prepare self-assemble Met-loaded TA nanoparticles (NPs). NPs exhibit excellent reactive oxygen scavenging capability, stability various media, an acid-responsive release Met. Vitro experiments showed that possess biocompatibility, effectively protecting chondrocyte viability OA's pathological environment preventing senescence phenotype. addition, promoted expression elements chondrocytes, restored membrane potential, enhanced mitocytosis improve quality. vivo further confirmed intra-articular injection rats post-traumatic OA improves cartilage matrix degradation, osteophyte formation, subchondral bone sclerosis over 8 weeks. Tissue staining protective mitochondria. Importantly, both vitro revealed provided superior cellular protection compared or Met alone. Overall, study demonstrates against degeneration, advantages easy preparation, high efficiency, biosafety.

Language: Английский

Citations

0
Smart self-healing hydrogel wound dressings for diabetic wound treatment DOI

Yuelin Hu,

Dejia Xv,

Chaoming Xie

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Feb. 18, 2025

Diabetic wounds are difficult to treat clinically because they heal poorly, often leading severe complications such as infections and amputations. Hydrogels with smart self-healing properties show great promise for treating diabetic wounds. These hydrogels capable of continuously dynamically responding changes in the wound environment, feature improved mechanical qualities capacity self-heal damage. We explore latest developments healing this review. First, we systematically summarize obstacles then highlighted significance hydrogels, explaining their stimulus-responsive mechanisms design approaches, along applications addressing these challenges. Finally, discussed unresolved potential avenues future research. anticipate that review will facilitate continued refinement dressings, aiming broader clinical adoption.

Language: Английский

Citations

0
Injectable sodium alginate/4-arm polyethylene glycol-lipoic acid double-network hydrogel loading Ca2+-tannic acid nanocomposite treats periodontitis via anti-bacteria, ROS scavenging and osteogenesis DOI
Ming Ouyang, Xi Yu, Jun Zhong

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 307, P. 141841 - 141841

Published: March 8, 2025

Language: Английский

Citations

0
3D printed eutectogel dissolving microneedles patch loaded with chitosan-based nanoparticles for diabetic wound management DOI
Huan Liu,

Aminov Nail,

Decheng Meng

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 307, P. 142018 - 142018

Published: March 12, 2025

Language: Английский

Citations

0
Anti-inflammatory MXene- and tannic acid-based synthetic-natural hybrid hydrogel for diabetic wound treatment by electrostimulation DOI
Ziru Liu, Xiangyu Chen, Biao Jin

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158615 - 158615

Published: Dec. 1, 2024

Language: Английский

Citations

1
Dandelion-shaped strontium-gallium microparticles for the hierarchical stimulation and comprehensive regulation of wound healing DOI Creative Commons

Minrui Ji,

Zaixin Yuan,

Hongdong Ma

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract The management of full-thickness skin injuries continues to pose significant challenges. Currently, there is a dearth comprehensive dressings capable integrating all stages wound healing spatiotemporally regulate biological processes following injuries. In this study, we report the synthesis dandelion-shaped mesoporous strontium-gallium microparticle (GE@SrTPP) achieved through dopamine-mediated strontium ion biomineralization and self-assembly, followed by functionalization with gallium metal polyphenol networks. As multifunctional dressing, GE@SrTPP can release bioactive ions in spatiotemporal manner akin dandelion seeds. During early healing, demonstrates rapid effective hemostatic performance while also exhibiting antibacterial properties. inflammatory phase, promotes M2 polarization macrophages, suppresses expression pro-inflammatory factors, decreases oxidative stress wounds. Subsequently, during proliferation tissue remodeling, facilitates angiogenesis activation Hypoxia-inducible factor-1α/vascular endothelial growth factor (HIF-1α/VEGF) pathway. Analogous dispersion rooting seeds, root-like new blood vessels supply essential nutrients for healing. Ultimately, rat chronic model, successful repair. summary, these microparticles demonstrate regulatory effects managing wounds, making them highly promising materials clinical applications.

Language: Английский

Citations

0