The Age‐Dependent Anticancer Efficacy of Agaricus blazei Murill Polysaccharide in Colon Cancer

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

ABSTRACT Agaricus blazei Murill polysaccharide (ABMP) has been found to exhibit significant immune regulatory effects, making them a promising candidate for complementary the pharmacological treatment of colorectal cancer immune‐related diseases. As prevalence among younger individuals increases, possible age‐dependent anticancer modulatory effect ABMP not clarified. This study evaluated immunoregulatory efficacy polysaccharides extraction from A. in colon tumor. Hematoxylin‐eosin staining, immunohistochemistry, and vibrational spectroscopic image analysis subcutaneous tumor tissues after preventive intervention 14 weeks were analyzed depth. In vivo data demonstrated that could more effectively inhibit growth mice at 8 compared with 12 months old without toxic side effect. Concurrently, Raman imaging spectroscopy showed significantly reduce lipid content microenvironment (TME) 8‐month‐old tumor‐bearing mice, suggesting changes TME are closely related activity. These results stress importance considering age as factor adjuvant therapy. work highlights first time is key determinant effectiveness by affecting levels thereby exerting

Language: Английский

Research progress on the bioactivity of compound polysaccharides: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141693 - 141693

Published: March 1, 2025

Language: Английский

Preventive intervention with Agaricus blazei murill polysaccharide exerts anti-tumor immune effect on intraperitoneal metastasis colorectal cancer

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136810 - 136810

Published: Oct. 1, 2024

Language: Английский