A pH-modulated polymeric drug-release system simultaneously combats biofilms and planktonic bacteria to eliminate bacterial biofilm

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156223 - 156223

Published: Sept. 1, 2024

Language: Английский

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Optimization of Haskap Extract and Tannic Acid Combined with Mild Heat Treatment: A Predictive Study on the Inhibition of Cronobacter sakazakii

Foods, Journal Year: 2025, Volume and Issue: 14(4), P. 562 - 562

Published: Feb. 8, 2025

Cronobacter sakazakii is an opportunistic food-borne pathogen that causes severe infections with high morbidity and mortality rates in neonates, the elderly, immunocompromised individuals. The plant extracts containing natural antibacterial compounds are currently under consideration as alternatives to synthetic artificial preservatives for control of C. sakazakii. There has been increasing interest using plant-derived antimicrobials combination mild heat pathogens preservative-free foods. In this study, individual combined effects four independent variables, i.e., polyphenol-rich haskap extract (HE) concentration (2-10%), tannic acid (TA) (0.1-0.5), temperature (35-55 °C), time (1-5 min), on inactivation were investigated by response surface methodology (RSM) a five-level factor central composite design (CCD) optimal maximum inhibition was determined. statistic metrics R2, R2adjusted, R2predicted, coefficient variation (CV), Predicted Residual Error Sum Squares (PRESSs), adequate precision, lack-of-fit used reveal prediction performance. results revealed all except time, influenced inactivation. Among most effective variable (p < 0.0001) regards synergistic HE TA observed. Many possible optimum conditions treatment maximized obtained. findings indicated two distinct combinations identified sakazakii: at low concentration. It can be concluded polyphenol extract, alone or acid, potential preservative reduce risk

Language: Английский

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AChE Inhibition Capability of Nanogels Derived from Natural Molecules: Tannic Acid and Lysine for Alzheimer’s Disease

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 502 - 502

Published: April 10, 2025

Background/Objectives: Tannic acid (TA), a known natural polyphenolic with many bioactivities including antioxidants, antibacterial, and antiviral, can be combined essential amino L-lysine (LYS) in nanogel formulations to produce p(TA-co-LYS) (p(TA-co-LYS)) nanogels. Methods: A 1:1 mole ratio of TA:LYS was used prepare corresponding spherical nanogels employing formaldehyde as linker via the Mannich reaction. Results: The attained particles were 283 ± 57 nm size ranges (via SEM analysis) possessed smooth surfaces. zeta potential measurements suspension at different solution pHs revealed isoelectric point (IEP) pH 4.9, suggesting that are negatively charged physiological range (e.g., 7.4). In addition antioxidant efficacy confirmed by three tests, showed significant Fe(II) ion chelating capacity 350 µg/mL concentrations compared bare TA, which is 21%, whereas LYS molecule had 100% same concentrations. Moreover, it found inhibited Acetylcholinesterase enzyme (AChE) concentration-dependent profile, e.g., 333 concentration p(TA-co-LYS), 57.2% AChE activity inhibited. Furthermore, minimum inhibition Gram-negative Escherichia coli (ATCC 8739) Gram-positive Staphylococcus aureus 6538) determined 12.5 mg/mL. Conclusions: As cytotoxicity studies on L929 fibroblast cells also ascertained these safely biomedical applications, materials, drug delivery devices, inhibitors.

Language: Английский

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Hydrogel-antimicrobial peptide association: A novel and promising strategy to combat resistant infections

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 247, P. 114451 - 114451

Published: Dec. 11, 2024

Language: Английский

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