Multifunctional Hydrogel Microneedles (HMNs) in Drug Delivery and Diagnostics
Gels,
Journal Year:
2025,
Volume and Issue:
11(3), P. 206 - 206
Published: March 15, 2025
Hydrogel
microneedles
(HMNs)
have
emerged
as
a
transformative
platform
for
minimally
invasive
drug
delivery
and
biosensing,
offering
enhanced
bioavailability,
controlled
release,
real-time
biomarker
detection.
By
leveraging
swelling
hydrogels,
nanomaterial
integration,
stimuli-responsive
properties,
HMNs
provide
precision
medicine
capabilities
across
diverse
therapeutic
diagnostic
applications.
However,
challenges
remain
in
mechanical
stability,
hydrogel-based
MNs
must
balance
flexibility
with
sufficient
strength
skin
penetration.
Drug
retention
release
require
optimization
to
prevent
premature
diffusion
ensure
sustained
effects.
Additionally,
biosensing
accuracy
is
influenced
by
variability
interstitial
fluid
extraction
signal
transduction.
Clinical
translation
hindered
regulatory
hurdles,
scalability
concerns,
the
need
extensive
safety
validation
human
trials.
This
review
critically
examines
key
materials,
fabrication
techniques,
functional
testing
frameworks
of
while
addressing
these
limitations.
Furthermore,
we
explore
future
research
directions
smart
wearable
MNs,
AI-assisted
hybrid
drug–device
platforms
optimize
transdermal
medicine.
Overcoming
barriers
will
drive
clinical
adoption
HMNs,
paving
way
next-generation
patient-centered
therapeutics
diagnostics.
Language: Английский
Advanced therapeutic strategies using Thermo-sensitive chitosan/pectin hydrogel in the treatment of multiple cancers
Tosha Pandya,
No information about this author
Disha Joshi,
No information about this author
Zenab Presswala
No information about this author
et al.
Carbohydrate Polymers,
Journal Year:
2025,
Volume and Issue:
357, P. 123454 - 123454
Published: Feb. 27, 2025
Language: Английский
Enhancing melanoma therapy with hydrogel microneedles
Leilei Zhu,
No information about this author
Ge Qiao,
No information about this author
Hongwei Gao
No information about this author
et al.
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
15
Published: April 17, 2025
Melanoma
is
highly
invasive
and
resistant
to
conventional
treatments,
accounting
for
nearly
75%
of
skin
cancer-related
deaths
globally.
Traditional
therapies,
such
as
chemotherapy
immunotherapy,
often
exhibit
limited
efficacy
are
associated
with
significant
side
effects
due
systemic
drug
exposure.
Microneedles
(MNs),
an
emerging
delivery
system,
offer
multiple
advantages,
including
safety,
painlessness,
minimal
invasiveness,
controlled
release.
Among
these,
hydrogel
microneedles
(HMNs)
stand
out
their
extracellular
matrix-like
structure
swelling-induced
continuous
channels,
which
enable
the
direct
therapeutic
agents
into
tumor
microenvironment
(TME).
This
approach
enhances
bioavailability
while
reducing
toxicity,
establishing
HMNs
a
promising
platform
melanoma
treatment.
review
highlights
recent
advancements
in
therapy,
focusing
on
applications
biomarker
extraction
early
diagnosis
role
supporting
multimodal
treatment
strategies,
chemotherapy,
phototherapy,
targeted
combination
therapy.
Furthermore,
current
matrix
materials
fabrication
techniques
discussed.
Finally,
limitations
critically
analyzed,
recommendations
future
research
development
provided.
Language: Английский
Artificial intelligence-driven hydrogel microneedle patches integrating 5-fluorouracil inclusion complex-loaded flexible pegylated liposomes for enhanced non-melanoma skin cancer treatment
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
unknown, P. 125072 - 125072
Published: Dec. 1, 2024
Language: Английский