ISO 10993-4 Compliant Hemocompatibility Evaluation of Gellan Gum Hybrid Hydrogels for Biomedical Applications DOI Creative Commons
Mthabisi Talent George Moyo, Terin Adalı, Oğuz Han Edebal

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 824 - 824

Published: Dec. 13, 2024

This study examines the hemocompatibility of gellan-gum-based hybrid hydrogels, with varying gellan-gum concentrations and constant sodium alginate silk fibroin concentrations, respectively, in accordance ISO 10993-4 standards. While previous studies have focused on cytocompatibility, these hydrogels remains underexplored. Hydrogels were formulated 0.3%, 0.5%, 0.75%, 1% gellan gum combined 3% 4.2% separately, using physical ionic cross-linking. Swelling behavior was analyzed phosphate (pH 7.4) acetic 1.2) buffers surface morphology examined by scanning electron microscopy (SEM). Hemocompatibility tests included complete blood count (CBC), coagulation assays, hemolysis index, erythrocyte morphology, platelet adhesion analysis. Results showed that gum–sodium exhibited faster swelling than gum–silk formulations. SEM indicated smoother surfaces alginate, while increased roughness, further amplified higher concentrations. assays confirmed normal profiles formulations 0.75% gum, caused significant hemolytic thrombogenic activity. These findings highlight excellent especially variants, supporting their potential bioengineering, tissue engineering, blood-contacting biomedical applications.

Language: Английский

Intratumoral delivery of Mitomycin C using bio-responsive Gellan Gum Nanogel: In-vitro evaluation and enhanced chemotherapeutic efficacy DOI

Nikhil Rai,

Disha Marwaha,

Shalini Gautam

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140306 - 140306

Published: Jan. 1, 2025

Language: Английский

Citations

1
Fabrication and Characterization of Curcumin and Piperine Loaded CMTG/rGO Electrospun for Breast Cancer Treatment DOI
Prabhakar Orsu,

Vimal Ch

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: March 7, 2025

Language: Английский

Citations

0
Shaping the future of medicine through diverse therapeutic applications of tetralin derivatives DOI

Bhumi Shah,

Radhika Kachhadiya

Medicinal Chemistry Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Language: Английский

Citations

2
An innovative rheology analysis method applies to the formulation optimization of Panax notoginseng total saponins ocular gel DOI

Hong Xu,

Chen Zang,

Fangbo Zhang

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 19

Published: Sept. 27, 2024

Emphasizing the viscoelasticity of ophthalmic gels is crucial for understanding residence time, structure, and stability hydrogels. This study primarily aimed to propose an innovative rheology analysis method gels, considering complex eye movements. was applied select with favorable rheological characteristics. Additionally, physical characteristics

Language: Английский

Citations

0
Fabrication and characterization of Curcumin and Piperine loaded CMTG/rGO Electrospun for breast cancer treatment DOI Creative Commons
Prabhakar Orsu,

Vimal Ch

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Abstract The development of multi-drug-loaded electrospun nanocomposites with superior biomimetic properties and controlled release capabilities is critical for advancing breast cancer treatment. In this study, we introduce nanocomposite fibers composed reduced graphene oxide (rGO) carboxymethyl tamarind gum (CMTG), which are coated curcumin piperine to achieve targeted drug delivery at tumor sites. Both rGO CMTG act as stabilizing agents potent antioxidant activity enhanced biocompatibility. synthesized rGO/CMTG was extensively characterized using functional, crystallographic, surface morphology analyses, confirming the formation an amorphous structure. vitro studies demonstrated nanocomposite’s high loading efficiency sustained profile. Additionally, cytotoxicity assays MDA-MB-231 human cells revealed that effectively induced cell death a favorable IC50 value. These findings suggest nanofiber-based systems hold significant promise therapeutic platform

Language: Английский

Citations

0
Synthesis and characterization of polyacrylamide-based antibacterial hydrogel nanocomposite DOI

Hassan Fathinejad,

Ebrahim Zohourvahid Karimi

Soft Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 8

Published: Nov. 24, 2024

In this research, the hydrogel nanocomposites based on acryl amide containing penicillin 800, 1200, Ag, and ZnO nanoparticles as wound dressing applications have been studied. work, preparation was done via a reaction of optimal values to produce an antibacterial nanocomposite. The obtained in aqueous medium by using reagents such acrylamide, potassium persulfate, methylene bisacrylamide crosslinker, nanoparticles, penicillins then, products were dried white powders. properties swelling rate, pH sensitivity, high water capacity rate study showed absorption about 3–4. effect temperature percentage shown swell with increasing polyacrylamide hydrogels decreased NaCl concentration. chemical structure confirmed FTIR spectrum, morphology synthesized surfaces studied SEM. studies blood, agar, chocolate, Müller three methods, first gram-negative bacteria E. coli Klebsiella, second urine medium, third drug medium. This polymeric blend can be used new compound.

Language: Английский

Citations

0
ISO 10993-4 Compliant Hemocompatibility Evaluation of Gellan Gum Hybrid Hydrogels for Biomedical Applications DOI Creative Commons
Mthabisi Talent George Moyo, Terin Adalı, Oğuz Han Edebal

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 824 - 824

Published: Dec. 13, 2024

This study examines the hemocompatibility of gellan-gum-based hybrid hydrogels, with varying gellan-gum concentrations and constant sodium alginate silk fibroin concentrations, respectively, in accordance ISO 10993-4 standards. While previous studies have focused on cytocompatibility, these hydrogels remains underexplored. Hydrogels were formulated 0.3%, 0.5%, 0.75%, 1% gellan gum combined 3% 4.2% separately, using physical ionic cross-linking. Swelling behavior was analyzed phosphate (pH 7.4) acetic 1.2) buffers surface morphology examined by scanning electron microscopy (SEM). Hemocompatibility tests included complete blood count (CBC), coagulation assays, hemolysis index, erythrocyte morphology, platelet adhesion analysis. Results showed that gum–sodium exhibited faster swelling than gum–silk formulations. SEM indicated smoother surfaces alginate, while increased roughness, further amplified higher concentrations. assays confirmed normal profiles formulations 0.75% gum, caused significant hemolytic thrombogenic activity. These findings highlight excellent especially variants, supporting their potential bioengineering, tissue engineering, blood-contacting biomedical applications.

Language: Английский

Citations

0