Self-supply of hydrogen peroxide by a bimetal-based nanocatalytic platform to enhance chemodynamic therapy for tumor treatment DOI

Tingxuan Yan,

Jiahao Su,

Tian‐Hao Yan

et al.

Nanotechnology, Journal Year: 2024, Volume and Issue: 36(4), P. 045101 - 045101

Published: Oct. 30, 2024

Abstract The tumor microenvironment (TME) is characterized by low pH, hypoxia, and overexpression of glutathione (GSH). Owing to the complexity pathogenesis heterogeneity TME, achieving satisfactory efficacy with a single treatment method difficult, which significantly impedes treatment. In this study, composite nanoparticles calcium-copper/alginate-hyaluronic acid (HA) (CaO 2 -CuO @SA/HA NC) pH GSH responsiveness were prepared for first time through one-step synthesis using HA as targeting ligand. Nanoparticles loaded H O can enhance chemodynamic therapy effects. Simultaneously, Cu 2+ generate oxygen in TME alleviate hypoxia tissue. undergo Fenton reaction produce cytotoxic hydroxyl radicals Ca ions, localization clearance cells. Additionally, sodium alginate (SA) utilized improve biocompatibility nanoparticles. Fourier transform infrared, x-ray diffraction, dynamic light scattering, SEM, transmission electron microscope, other analytical methods used investigate their physical chemical properties. results indicate that CaO NC had particle size 220 nm, narrow distribution, uniform morphology. hydrogen peroxide self-supplied nanodrug delivery system exhibited excellent pH-responsive release performance glutathione-responsive •OH ability while also reducing level reactive oxide species quenching. vitro cell experiments, no obvious side effects on normal tissues observed; however, inhibition rate malignant tumors HepG2 DU145 exceeded 50%. preparation nanoparticles, achieve both chemokinetic ion interference therapy, has demonstrated significant potential clinical applications cancer therapy.

Language: Английский

Recent Advances in Metal–Organic Framework-Based Anticancer Hydrogels DOI Creative Commons
Preeti Kush, Ranjit Singh, Parveen Kumar

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 76 - 76

Published: Jan. 18, 2025

Cancer is the second leading cause of death globally and estimated number new cancer cases deaths will be ∼30.2 million 16.3 million, respectively, by 2040. These numbers massive, physical, emotional, financial burdens to society healthcare system that lead further research for a better more effective therapeutic strategy manage cancer. Metal–organic frameworks (MOFs) are promising alternative approaches efficient drug delivery theranostics owing their unique properties direct transportation drugs into cells followed controlled release, but they suffer from certain limitations like rigidity, poor dispersibility, fragility, aggregation probability, limited surface accessibility. Therefore, MOFs were conjugated with polymeric hydrogels, formation MOF-based hydrogels abundant absorption sites, flexibility, excellent mechanical properties. This review briefly describes different strategies used synthesis characterization hydrogels. Further, we place special emphasis on recent advances in cancers. Finally, conclude challenges future perspectives We believe this help researchers develop augmented anticancer effects, enabling management even without adverse effects.

Language: Английский

Citations

1
A polysaccharide from Agelas aff. Nemoechinata sponge: Structure and potential anti-liver cancer activity evaluation DOI

Teng Wang,

Mengyao Hu, Huilin Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141412 - 141412

Published: Feb. 1, 2025

Language: Английский

Citations

0
Precise size control of superparamagnetic Fe3O4 nanoparticles for liver cancer diagnosis and magnetic hyperthermia therapy DOI
Linxue Zhang, Qifan Li, Junxiao Liu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114763 - 114763

Published: May 1, 2025

Language: Английский

Citations

0
Self-supply of hydrogen peroxide by a bimetal-based nanocatalytic platform to enhance chemodynamic therapy for tumor treatment DOI

Tingxuan Yan,

Jiahao Su,

Tian‐Hao Yan

et al.

Nanotechnology, Journal Year: 2024, Volume and Issue: 36(4), P. 045101 - 045101

Published: Oct. 30, 2024

Abstract The tumor microenvironment (TME) is characterized by low pH, hypoxia, and overexpression of glutathione (GSH). Owing to the complexity pathogenesis heterogeneity TME, achieving satisfactory efficacy with a single treatment method difficult, which significantly impedes treatment. In this study, composite nanoparticles calcium-copper/alginate-hyaluronic acid (HA) (CaO 2 -CuO @SA/HA NC) pH GSH responsiveness were prepared for first time through one-step synthesis using HA as targeting ligand. Nanoparticles loaded H O can enhance chemodynamic therapy effects. Simultaneously, Cu 2+ generate oxygen in TME alleviate hypoxia tissue. undergo Fenton reaction produce cytotoxic hydroxyl radicals Ca ions, localization clearance cells. Additionally, sodium alginate (SA) utilized improve biocompatibility nanoparticles. Fourier transform infrared, x-ray diffraction, dynamic light scattering, SEM, transmission electron microscope, other analytical methods used investigate their physical chemical properties. results indicate that CaO NC had particle size 220 nm, narrow distribution, uniform morphology. hydrogen peroxide self-supplied nanodrug delivery system exhibited excellent pH-responsive release performance glutathione-responsive •OH ability while also reducing level reactive oxide species quenching. vitro cell experiments, no obvious side effects on normal tissues observed; however, inhibition rate malignant tumors HepG2 DU145 exceeded 50%. preparation nanoparticles, achieve both chemokinetic ion interference therapy, has demonstrated significant potential clinical applications cancer therapy.

Language: Английский

Citations

0