Molecular crosstalk in SP7-mediated osteogenesis: Regulatory mechanisms and therapeutic potential DOI Creative Commons
Jun Lang, Vivek Kumar Morya, Mi Kyung Kwak

et al.

Osteoporosis and Sarcopenia, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Targeting sirtuins for cancer therapy: epigenetics modifications and beyond DOI Creative Commons
Hui Shen,

Xinyi Qi,

Yue Hu

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 14(17), P. 6726 - 6767

Published: Jan. 1, 2024

Sirtuins (SIRTs) are well-known as nicotinic adenine dinucleotide

Language: Английский

Citations

9
Role of SIRT7 in Prostate Cancer Progression: New Insight Into Potential Therapeutic Target DOI Creative Commons
Jiale Zhang,

Chenxin Liu,

Wenting Luo

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(7)

Published: April 1, 2025

ABSTRACT Prostate cancer (PCa) is the second most common in men worldwide, and understanding its molecular mechanisms crucial for developing effective treatment strategies. SIRT7, a NAD+‐dependent histone deacetylase, has emerged as key regulator PCa progression due to roles chromatin remodeling, DNA repair, transcriptional regulation. Analysis of 492 samples from The Cancer Genome Atlas (TCGA) via cBioPortal revealed that high SIRT7 expression associated with poor prognosis patients. Mechanistically, deacetylates H3 at lysine 18 (H3K18Ac), marker aggressive tumors, suppressing tumor suppressor genes promoting cell proliferation survival. Epithelial‐mesenchymal transition (EMT) cellular biological process which epithelial cells undergo specific morphological changes transform into characteristics mesenchymal cells. also regulates EMT, inhibiting lines reduces migration invasion, highlighting potential therapeutic target. In summary, clinical significance requires further research elucidate mechanisms. Developing inhibitors targeting SIRT7's deacetylase activity promising strategy. plays role regulating processes such proliferation, cycle, apoptosis through epigenetic control gene maintenance genomic stability. Therefore, may be target PCa, could have prognostic value patients, providing important guidance monitoring diagnosis by physicians.

Language: Английский

Citations

0
SIRT3/6/7: promising therapeutic targets for pulmonary fibrosis DOI Creative Commons
Pingping Huang, Qin Du,

Qin Yan-ling

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: April 2, 2025

Pulmonary fibrosis is a chronic progressive fibrosing interstitial lung disease of unknown cause, characterized by excessive deposition extracellular matrix, leading to irreversible decline in function and ultimately death due respiratory failure multiple complications. The Sirtuin family group nicotinamide adenine dinucleotide (NAD+) -dependent histone deacetylases, including SIRT1 SIRT7. They are involved various biological processes such as protein synthesis, metabolism, cell stress, inflammation, aging through deacetylation. This article reviews the complex molecular mechanisms poorly studied SIRT3, SIRT6, SIRT7 subtypes latest research progress targeting them treat fibrosis.

Language: Английский

Citations

0
Molecular crosstalk in SP7-mediated osteogenesis: Regulatory mechanisms and therapeutic potential DOI Creative Commons
Jun Lang, Vivek Kumar Morya, Mi Kyung Kwak

et al.

Osteoporosis and Sarcopenia, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0