Preparation and characterization of advancing wound care with PVP/QCS/DEX hydrogels: a multifunctional wound dressing composite: in vitro and in vivo assay DOI

Moosa Hatami,

Mohammad Taghi Khorasani, Ebrahim Ahmadi

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: April 17, 2025

Although the skin has a high healing capacity, severe wounds often require external interventions to heal properly. Tissue-engineered wound dressings have indeed gained significant attention among various treatment strategies for healing. This study focuses on integration of polyvinyl pyrrolidone (PVP), quaternized chitosan (QCS), and dextran (DEX) prepare ternary composite (PVP/QCS/DEX) as dressing hydrogels with varying concentration PVP DEX. A variety analytical methods, including infrared spectroscopy (FTIR), scanning electron microscopy (SEM), contact angle, water vapor transmission rate (WVTR) were employed assess characteristics samples. The uniform interconnected porous structure samples was confirmed by SEM results. All showed porosity transition rate, demonstrating their ability provide suitable moist environment efficient exudate handling antibacterial test conducted demonstrated activity drug-loaded hydrogel Escherichia coli Staphylococcus aureus. in vitro cytotoxicity evaluation using MTT assay that developed PVP/QCS/DEX exhibit satisfactory cytocompatibility promote cell viability. results scratch indicated had promoted migration would improve accelerate process. vivo tests sample revealed promising performance. Therefore, based favorable performance observed throughout analysis, as-prepared show promise field dressings.

Language: Английский

Synthesis of PVA-Based Hydrogels for Biomedical Applications: Recent Trends and Advances DOI Creative Commons
Mohammad Mizanur Rahman Khan, Md. Mahamudul Hasan Rumon

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 88 - 88

Published: Jan. 23, 2025

There is ongoing research for biomedical applications of polyvinyl alcohol (PVA)-based hydrogels; however, the execution this has not yet been achieved at an appropriate level commercialization. Advanced perception necessary design and synthesis suitable materials, such as PVA-based hydrogel applications. Among polymers, drawn great interest in owing to their attractive potential with characteristics good biocompatibility, mechanical strength, apposite water content. By designing approach investigating structure, hydrogels can attain superb cytocompatibility, flexibility, antimicrobial activities, signifying that it a candidate tissue engineering regenerative medicine, drug delivery, wound dressing, contact lenses, other fields. In review, we highlight current progresses on explaining diverse usage across variety areas. We explain numerous techniques related phenomena based these materials. This review may stipulate wide reference future acumens materials extensive

Language: Английский

Citations

1
Recent Advancements in Chitosan-Based Biomaterials for Wound Healing DOI Creative Commons

J.S. Shah,

Dhruv Patel,

Dnyaneshwari Rananavare

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(2), P. 45 - 45

Published: Jan. 30, 2025

Chitosan is a positively charged natural polymer with several properties conducive to wound-healing applications, such as biodegradability, structural integrity, hydrophilicity, adhesiveness tissue, and bacteriostatic potential. Along other mechanical properties, some of the discussed in this review are antibacterial mucoadhesive biocompatibility, high fluid absorption capacity, anti-inflammatory response. forms stable complexes oppositely polymers, arising from electrostatic interactions between (+) amino groups chitosan (−) polymers. These polyelectrolyte (PECs) can be manufactured using various materials methods, which brings diversity formulations that optimized for specific wound healing well applications. For example, chitosan-based PEC made into dressings/films, hydrogels, membranes. There pros cons associated manufacturing dressings; instance, layer-by-layer casting technique optimize nanoparticle release affect strength due formation heterostructure. Furthermore, chitosan’s molecular weight degree deacetylation, nature negatively biomaterial it cross-linked, major factors govern biodegradation kinetics dressing. The use care products forecasted drive growth global market, expected increase by approximately 14.3% within next decade. This driven chitoderm-containing ointments, provide scaffolding skin cell regeneration. Despite significant advancements, there remains critical gap translating biomaterials research clinical

Language: Английский

Citations

1
Multifunctional hydrogel scaffolds based on polysaccharides and polymer matrices promote bone repair: A review DOI

Chang Bing Shen,

Yuanyuan Han, Huan Xiong

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 294, P. 139418 - 139418

Published: Jan. 5, 2025

Language: Английский

Citations

0
Synthesis and Characterization of Antibacterial Poly{2‐[(methacryloyloxy)ethyl]trimethylammonium Chloride}/Chitosan Semi‐Interpenetrating Networks for Papain Release DOI Open Access
Carolina Cruz Ferreira, Guilherme Frey Schutz, Lucas Novaes Teixeira

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Annually, thousands of individuals suffer from skin injuries resulting trauma, surgeries, or diabetes. Inadequate wound treatment can delay healing and increase the risk severe infections. In this context, a promising synthetic polymer with potent antimicrobial properties, Poly{2-[(methacryloyloxy)ethyl]trimethylammonium chloride} (PMETAC), is synthesized crosslinked N,N'-Methylenebis(acrylamide) (BIS) in presence Chitosan (CH), natural, biocompatible polysaccharide that promotes cell regeneration provides additional beneficial properties. These semi-interpenetrating (semi-IPN) networks are chosen as matrix for releasing papain, proteolytic enzyme debridement By integrating properties materials, study evaluates PMETAC-based hydrogels different CH concentrations (5%, 10%, 25%) to understand their physicochemical biological performance, including antibacterial activity cytocompatibility. incorporating 25% led 19% pore size 48% maximum volume compared control PMETAC hydrogel. Additionally, all formulations demonstrate ≈100% reduction E. coli S. aureus, showcasing remarkable efficacy. The inclusion also significantly improves fibroblast viability, formulation standing out most candidate multifunctional dressings, highlighting potential hard-to-heal wounds regenerative medicine.

Language: Английский

Citations

0
A photothermal antimicrobial, antioxidant hydrogel for healing of bacterial-infected wounds DOI

Junqi Zhao,

Ying Chen,

Qing Dong Zhong

et al.

Polymer, Journal Year: 2025, Volume and Issue: unknown, P. 128332 - 128332

Published: March 1, 2025

Language: Английский

Citations

0
Preparation and characterization of advancing wound care with PVP/QCS/DEX hydrogels: a multifunctional wound dressing composite: in vitro and in vivo assay DOI

Moosa Hatami,

Mohammad Taghi Khorasani, Ebrahim Ahmadi

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: April 17, 2025

Although the skin has a high healing capacity, severe wounds often require external interventions to heal properly. Tissue-engineered wound dressings have indeed gained significant attention among various treatment strategies for healing. This study focuses on integration of polyvinyl pyrrolidone (PVP), quaternized chitosan (QCS), and dextran (DEX) prepare ternary composite (PVP/QCS/DEX) as dressing hydrogels with varying concentration PVP DEX. A variety analytical methods, including infrared spectroscopy (FTIR), scanning electron microscopy (SEM), contact angle, water vapor transmission rate (WVTR) were employed assess characteristics samples. The uniform interconnected porous structure samples was confirmed by SEM results. All showed porosity transition rate, demonstrating their ability provide suitable moist environment efficient exudate handling antibacterial test conducted demonstrated activity drug-loaded hydrogel Escherichia coli Staphylococcus aureus. in vitro cytotoxicity evaluation using MTT assay that developed PVP/QCS/DEX exhibit satisfactory cytocompatibility promote cell viability. results scratch indicated had promoted migration would improve accelerate process. vivo tests sample revealed promising performance. Therefore, based favorable performance observed throughout analysis, as-prepared show promise field dressings.

Language: Английский

Citations

0