Anti-hyperuricemia effects of a polysaccharide-protein complex from Lentinula edodes mediated by gut-kidney axis DOI
Xinyi Xiong, Peng Liu, Liping Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 293, P. 139370 - 139370

Published: Dec. 30, 2024

Language: Английский

S-nitrosylation of peroxiredoxin 2 exacerbates hyperuricemia-induced renal injury through regulation of mitochondrial homeostasis DOI Creative Commons
Fei Han,

Ya Dong,

Qiaoyan Liu

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
The Potential Mechanism of Alpiniae oxyphyllae Fructus Against Hyperuricemia: An Integration of Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Experiments DOI Open Access

Shuanggou Zhang,

Yuanfei Yang,

Ruohan Zhang

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 71 - 71

Published: Dec. 28, 2024

Background: Alpiniae oxyphyllae Fructus (AOF) is a medicinal and edible resource that holds potential to ameliorate hyperuricemia (HUA), yet its mechanism of action warrants further investigation. Methods: We performed network pharmacology, molecular docking, dynamics simulation, in vitro experiments investigate the AOF against HUA. Results: The results indicate 48 anti-HUA targets for 4 components derived from were excavated predicted through public databases. Gene Ontology (GO) enrichment analysis indicated there are 190 entries related biological process, 24 cellular component, 42 function, 44 Kyoto Encyclopedia Genes Genomes (KEGG) signaling pathways. docking showed main active ingredients may have therapeutic effects on immune system disorders inflammation caused by HUA binding including peroxisome-proliferator-activated receptor gamma (PPARG), estrogen 1 (ESR1), prostaglandin G/H synthase 2 (PTGS2), 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). Subsequently, we determined stability complex between core ingredient target proteins simulation. cell demonstrated stigmasterol as significantly upregulated expression levels ESR1 PPARG (p < 0.001) exert an effect. Conclusions: In summary, systematically elucidated mainly their pharmacological acting multiple this study. Our studies will provide scientific basis precise development utilization AOF.

Language: Английский

Citations

4
Genome-wide transcriptome analysis of gene expression profiles in Goose Astrovirus-infected GEF cells DOI
Xiaozhan Zhang,

Saimin Zhai,

Yunze Guo

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107343 - 107343

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Role of Dietary Polysaccharides in Uric Acid Regulation: Mechanisms and Benefits in Managing Hyperuricemia DOI

Wenchen Yu,

Jia‐Ren Liu, Denis Baranenko

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104902 - 104902

Published: Feb. 1, 2025

Language: Английский

Citations

0
Untargeted Metabolomics and Network Pharmacology Reveal the Uric Acid-Lowering Effects of Alcohol Extract of Gnaphalium affine and Its Extracts in Hyperuricemic Rats DOI

Chen Wang,

Xinchao He,

L. Venkateswar Rao

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106471 - 106471

Published: March 1, 2025

Language: Английский

Citations

0
Research Progress on the Extraction, Structure Elucidation, Biological Activities, and Drug Carrier Applications of Polygonati Rhizom Polysaccharides DOI Creative Commons

Q. Xu,

Qiuyue Lv,

Zhu Yang

et al.

Journal of Food Biochemistry, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

As widely used in traditional Chinese medicine and nutritional food, Polygonati Rhizom is known for its diverse pharmacological properties, including hematopoiesis, immune enhancement, antitumor, anti‐inflammatory, antioxidant, antiaging, antiviral, hepatoprotection. polysaccharides (PRPs) are primary bioactive compounds that water‐soluble mainly comprise fructose (Fru), glucose (Glc), galactose (Gal), arabinose (Ara), rhamnose (Rha), fucose (Fuc), xylose (Xyl), glucuronic acid (GlcA), galacturonic (GalA). Meanwhile, different extraction methods, such as hot water ultrasonic extractions, can significantly affect the yield of PRPs, Additionally, PRPs were also reported to hold promising potential a drug carrier. Herein, extraction, structure elucidation, biological activities, carrier applications systematically summarized, providing reference further research development Rhizom.

Language: Английский

Citations

0
Extraction, purification, structural characterization, biological activity, structure-activity relationship, and applications of polysaccharides derived from Polygonatum sibiricum: A review DOI
Jiewei Wu, Chang Tan, Hongye Li

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 105038 - 105038

Published: April 1, 2025

Language: Английский

Citations

0
Quality Assessment of Polygonatum cyrtonema Hua from Multiple Origins and Cultivation Modes via UPLC-Q-Exactive-MS/MS-Based Untargeted Metabolomics DOI
Fang‐Kun Peng, Chunxiao Li, Hang Liu

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106713 - 106713

Published: April 1, 2025

Language: Английский

Citations

0
Uric acid metabolism regulation mechanism by probiotics and prebiotics: from a new perspective DOI

Jiageng Cheng,

Y. J. Su, Yifan Wu

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 105076 - 105076

Published: May 1, 2025

Language: Английский

Citations

0
Natural polysaccharides in the prevention of hyperuricemia: Source, classification, mechanism, application in food industry DOI
Likun Ren, Lei Dang, Dangfeng Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 286, P. 138421 - 138421

Published: Dec. 6, 2024

Language: Английский

Citations

2