Lysosomal Ion Channels and Transporters: Recent Findings, Therapeutic Potential, and Technical Approaches

Bioelectricity, Journal Year: 2025, Volume and Issue: 7(1), P. 29 - 57

Published: March 1, 2025

In recent years, there has been a growing interest in lysosomal ion channels and transporters due to their critical role maintaining function involvement variety of diseases, particularly storage cancer, neurodegenerative disorders. Recent advancements research techniques, including manual automated patch clamp (APC) electrophysiology, solid-supported membrane-based electrophysiology (SSME), fluorescence-based imaging, have further enhanced our ability investigate both physiological pathological conditions, spurring drug discovery efforts. Several pharmaceutical companies are now developing therapies aimed at modulating these improve disease. Small molecules targeting like transient receptor potential mucolipin (TRPML) 1 TMEM175, as well drugs pH, currently preclinical clinical development. This review provides an overview the health disease, highlights cutting-edge techniques used study them, discusses therapeutic treatment various diseases. Furthermore, addition summarizing discoveries, we contribute novel functional data on cystinosin, TRPML1, two-pore channel 2 (TPC2), utilizing SSME APC approaches.

Language: Английский

Genome editing: a novel approach to manage insect vectors of plant viruses

Insect Biochemistry and Molecular Biology, Journal Year: 2024, Volume and Issue: 174, P. 104189 - 104189

Published: Sept. 27, 2024

Language: Английский