The Role of Magnesium, Zinc, and Strontium in Osteoporotic Fracture Repair
Bioengineering,
Journal Year:
2025,
Volume and Issue:
12(2), P. 201 - 201
Published: Feb. 18, 2025
Osteoporotic
fractures
represent
a
significant
public
health
challenge
in
the
context
of
an
aging
global
population,
with
rising
prevalence
osteoporosis
intensifying
demand
for
effective
fracture
treatment.
Restoring
structure
and
function
bone
tissue
damaged
by
osteoporosis-induced
defects
remains
critical
issue
clinical
practice.
In
recent
years,
bioactive
metallic
materials
such
as
magnesium,
zinc,
strontium
have
gained
considerable
attention
due
to
their
exceptional
mechanical
properties,
biocompatibility,
biodegradability,
positioning
them
promising
osteoporotic
repair.
This
review
systematically
explored
biological
mechanisms,
application
advancements,
associated
challenges
healing.
Key
topics
included
roles
promoting
osteoblast
proliferation
differentiation,
inhibiting
osteoclast
activity,
modulating
microenvironment.
Additionally,
this
examined
optimization
strategies
application,
integration
into
scaffolds,
functionalization
conventional
materials,
synergistic
effects
between
different
metals.
Finally,
analyzed
current
progress
unresolved
issues
field,
offering
forward-looking
perspective
on
potential
precision
treatment
fractures.
Language: Английский
Directional extrusion preparation and properties of ordered porous gelatin/nano-hydroxyapatite bone tissue engineering scaffolds
Qing Jie,
No information about this author
Jiawei Tan,
No information about this author
Ting Xiao
No information about this author
et al.
Materials Letters,
Journal Year:
2025,
Volume and Issue:
unknown, P. 138351 - 138351
Published: March 1, 2025
Language: Английский
Engineered Peptides‐Based Hybrid‐Nested Microneedle Effectively Treat Biofilm‐Infected Diabetic Wounds
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 16, 2025
Abstract
Diabetic
wounds
with
biofilm
present
a
significant
challenge
in
wound
care,
often
leading
to
chronic
inflammation,
recurrent
infections,
impaired
healing,
and
severe
cases,
amputations.
Addressing
this
critical
requires
multifaceted
treatment
strategy.
Herein,
hybrid‐nested
microneedle
scaffold
(MQW‐CMg‐MOF)
designed
for
efficient
removal
is
reported
healing
of
diabetic
accelerated.
This
integrates
as
system:
the
bottom
layer
features
nested
patch
embedded
vancomycin,
antimicrobial
peptide
W379,
angiogenic
QK
peptide,
while
top
consists
chitosan
cryogels
incorporated
magnesium
metal–organic
frameworks.
The
patches
are
engineered
penetrate
mechanically
disrupt
biofilms
enable
programmed
release
agents,
effectively
addressing
infection
promoting
angiogenesis.
Simultaneously,
serve
substrate
scavenging
reactive
oxygen
species
supporting
cell
ingrowth.
show
substantial
vitro
preclinical
swine
biofilm‐infected
model
compared
control.
Most
importantly,
combined
arrays
combat
promote
type
2
(db/db)
mice.
Overall,
multifunctional
hybrid
system
shows
promise
facilitating
enhancing
wounds.
Language: Английский
Controllable preparation of hydrophilic alendronate hydroxyapatite quercetin multifunctional polylactic acid microspheres for treating osteoarthritis
Lifei Yang,
No information about this author
Jiawei Yao,
No information about this author
D. Shi
No information about this author
et al.
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
unknown, P. 143071 - 143071
Published: April 1, 2025
Language: Английский