Ganoderma lucidum Polysaccharide/carboxymethyl Chitosan Hydrogels Modulate Macrophage Polarization for Wound Healing DOI
Yu Zou, Yuheng Yang,

Jingying Pei

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Wound healing remains a global challenge for clinical and experimental research. Hydrogels prepared from natural polysaccharides show great potential in the wound process. In this study, novel hydrogels (G-GLP) were using oxidized Ganoderma lucidum (OGLPs) carboxymethyl chitosan via Schiff base reaction, which did not require addition of any chemical cross-linking agent. The showed excellent mechanical properties biocompatibility. Moreover, superior hemostatic performance mouse liver trauma tail amputation models. Importantly, G-GLP improved inflammation by promoting polarization macrophage M2 subtype, inhibiting M1 subtype reducing intracellular levels reactive oxygen species. vivo experiments demonstrated that accelerated total defect model blood vessel repair collagen deposition. These results demonstrate has as an effective dressing.

Language: Английский

Synthesis and Characterization of chemically functionalized Novel Smart Guar Gum Xanthate Based Hydrogel: Swelling, Isotherm, Kinetics, Thermodynamic and Reusability Studies DOI

Arbind Chaurasiya,

Poorn Prakash Pande, Ravi Shankar

et al.

Journal of Physics and Chemistry of Solids, Journal Year: 2025, Volume and Issue: unknown, P. 112584 - 112584

Published: Jan. 1, 2025

Language: Английский

Citations

2
Double cross-linked cellulose hydrogel-supported Fe species for efficient wound healing DOI Creative Commons

Mingyue Xue,

Xianglin Pei, Jian Zhang

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(10), P. 7885 - 7896

Published: Jan. 1, 2025

The physical/chemical double-crosslinked cellulose/Fe hydrogel is constructed from bio-based materials, which neutralizes reactive oxygen species, curbs inflammation and improves wound healing.

Language: Английский

Citations

0
Development of a thiol-maleimide crosslinked carboxymethyl guar gum hydrogel for sustained drug delivery DOI
Rua B. Alnoman, Hussam Y. Alharbi,

Majed S. Aljohani

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106633 - 106633

Published: Jan. 1, 2025

Language: Английский

Citations

0
Synthesis of Functional Pectin‐Based Hydrogels via Thiol‐Maleimide Click Reaction for Enhanced Drug Encapsulation and Release DOI Open Access
Hussam Y. Alharbi, Rua B. Alnoman,

Majed S. Aljohani

et al.

Journal of Applied Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

ABSTRACT This work describes the synthesis and characterization of a novel hydrogel system based on pectin (PT) functionalized with thiol maleimide groups cross‐linked by thiol‐maleimide click chemistry. Thiolated PT (PT‐SH) maleimide‐modified (PT‐Ma) precursors were synthesized carbodiimide‐mediated amidation confirmed elemental analysis, FTIR, 1H NMR spectroscopy. The resulting exhibited gelation efficiency over 80%, swelling degrees ranging from 44% to 80% depending cross‐linking density, pH‐sensitive behavior maximum at pH 8. demonstrated high mechanical stability, compressive strengths 20.8–33.2 kPa, increasing density. As model drug, ibuprofen was encapsulated efficiencies up 337 mg/g released in controlled fashion. In vitro release studies showed slower acidic environments, which ranged 22% 53% within 6–10 h, faster slightly alkaline environment, consistent profile hydrogel. Such properties underline hydrogel's potential for sustained drug delivery. Pectin hydrogels, upon cross‐linking, are hereby presented be strong platform biomedical applications properties, behavior, performance

Language: Английский

Citations

0
Ganoderma lucidum Polysaccharide/carboxymethyl Chitosan Hydrogels Modulate Macrophage Polarization for Wound Healing DOI
Yu Zou, Yuheng Yang,

Jingying Pei

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Wound healing remains a global challenge for clinical and experimental research. Hydrogels prepared from natural polysaccharides show great potential in the wound process. In this study, novel hydrogels (G-GLP) were using oxidized Ganoderma lucidum (OGLPs) carboxymethyl chitosan via Schiff base reaction, which did not require addition of any chemical cross-linking agent. The showed excellent mechanical properties biocompatibility. Moreover, superior hemostatic performance mouse liver trauma tail amputation models. Importantly, G-GLP improved inflammation by promoting polarization macrophage M2 subtype, inhibiting M1 subtype reducing intracellular levels reactive oxygen species. vivo experiments demonstrated that accelerated total defect model blood vessel repair collagen deposition. These results demonstrate has as an effective dressing.

Language: Английский

Citations

0