Triptophenolide aggravates triptolide-induced liver injury through disrupting the biological function of intestine
Binbin Zhang,
No information about this author
Qiuxia Lin,
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Manyun Dai
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et al.
Toxicology and Applied Pharmacology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 117354 - 117354
Published: April 1, 2025
Language: Английский
Mechanistic Advances in Hypoglycemic Effects of Natural Polysaccharides: Multi-Target Regulation of Glycometabolism and Gut Microbiota Crosstalk
Molecules,
Journal Year:
2025,
Volume and Issue:
30(9), P. 1980 - 1980
Published: April 29, 2025
Natural
polysaccharides
(NPs),
as
a
class
of
bioactive
macromolecules
with
multitarget
synergistic
regulatory
potential,
exhibit
significant
advantages
in
diabetes
intervention.
This
review
systematically
summarizes
the
core
hypoglycemic
mechanisms
NPs,
covering
structure–activity
relationships,
integration
gut
microbiota–metabolism–immunity
axis,
and
regulation
key
signaling
pathways.
Studies
demonstrate
that
molecular
weight,
branch
complexity,
chemical
modifications
NPs
mediate
their
activity
by
influencing
bioavailability
target
specificity.
improve
glucose
metabolism
through
multiple
pathways:
activating
insulin
signaling,
improving
resistance
(IR),
enhancing
glycogen
synthesis,
inhibiting
gluconeogenesis,
regulating
microbiota
homeostasis.
Additionally,
protect
pancreatic
β-cell
function
via
nuclear
factor
E2-related
2
(Nrf2)/Antioxidant
Response
Element
(ARE)
antioxidant
pathway
Toll-like
receptor
4
(TLR4)/nuclear
factor-κB
(NF-κB)
anti-inflammatory
pathway.
Clinical
application
still
requires
overcoming
challenges
such
resolving
complex
relationships
dynamically
integrating
cross-organ
signaling.
Future
research
should
focus
on
multi-omics
technologies
(e.g.,
metagenomics,
metabolomics)
organoid
models
to
decipher
action
networks
promote
translation
from
basic
clinical
applications.
Language: Английский
Preliminary characterization of Ramaria botrytoides polysaccharide RB-P1-1 and analysis of its hypoglycemic effects by altering the gut microbiota and metabolites in mice with type 2 diabetes mellitus
Zaizhong Ni,
No information about this author
Lingzhi Chen,
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Xinyi Qian
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et al.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
unknown, P. 138774 - 138774
Published: Dec. 1, 2024
Language: Английский