Development of Etoricoxib loaded mesoporous silica nanoparticles laden gel as vehicle for transdermal delivery: Optimization, ex-vivo permeation, histopathology and in-vivo anti-inflammatory study. DOI
Dibyalochan Mohanty,

N. G. Divya,

Ameeduzzafar Zafar

et al.

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: April 7, 2025

Etoricoxib (ETB) is a nonsteroidal anti-inflammatory therapeutic agent. It poorly soluble and has various gastrointestinal side effects such as bleeding ulcers after oral administration. The present research aimed to develop an ETB-loaded mesoporous silica nanoparticle-laden gel (ETB-MSNPs) for transdermal delivery improve efficacy. ETB-MSNPs were synthesized using precipitation solvent evaporation technique their optimization was performed Box-Behnken design. optimized incorporated into carbopol-chitosan evaluated in-vitro, ex-vivo, in-vivo activity. displayed nanosize of particles with distribution high entrapment efficiency ETB. FTIR DSC studies showed that ETB encapsulated in MSNPs. successfully integrated the carbopol chitosan gel, which exhibited excellent viscosity spreadability. significantly higher more sustained release compared pure gel. Optimized considerably effect significant reduction IL-1β TNF-α levels histopathological examination confirmed did not exhibit any toxicity on skin. Based findings, results suggest MSNPs potential carrier enhancing efficacy through topical delivery, although further are needed fully confirm its effectiveness.

Language: Английский

Azithromycin-Loaded Nanoparticles Incorporated in Chitosan-Based Soft Hydrogels: A Novel Approach for Dental Drug Delivery DOI Creative Commons

Jakub Kwiatek,

Magdalena Paczkowska-Walendowska, Anna Rył

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 304 - 304

Published: Feb. 26, 2025

Background: Azithromycin (AZC), a BCS class II/IV antibiotic with broad-spectrum antimicrobial activity, has poor water solubility, limiting its formulation potential. This study aimed to develop and optimize AZC-based soft hydrogels for the first time improved local controlled drug release, dental applications. Methods: AZC nanoparticles (based on polyvinylpyrrolidone) were synthesized via electrospinning enhanced solubility 40-fold. These incorporated into chitosan (CS) varying concentrations degrees of deacetylation (DDA), optimized using factorial design. Hydrogels characterized mucoadhesion, antioxidant, anti-inflammatory, properties, Principal Component Analysis (PCA) assessing correlations. Results: Soft 3% CS 80% DDA achieved sustained release (62.9–94.7% over 48 h), strong biological activity. Higher antioxidant anti-inflammatory effects due increased free amino groups. Antimicrobial tests showed efficacy against Streptococcus mutans Staphylococcus aureus. PCA revealed an inverse correlation between mucoadhesion positive correlations Conclusions: significantly showing potential delivery. Further clinical validation optimization are recommended.

Language: Английский

Citations

1
Formation and stabilization mechanism of Ginsenoside Rg3 inclusion complexes based on molecular simulation DOI

Shili Pan,

Wei Shen,

Xuehui Ding

et al.

Pharmaceutical Development and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 18

Published: Jan. 2, 2025

The formation of inclusion complexes between Ginsenoside Rg3 and cyclodextrins represents a promising strategy to enhance the solubility G-Rg3. Nevertheless, molecular mechanisms underlying interaction G-Rg3 have yet be fully elucidated. In this study, we employed combination simulation experimental methodologies identify most effective solubilizing carriers among G-Rg3, β-cyclodextrin (β-CD), 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), 2,6-dimethyl-β-cyclodextrin (DM-β-CD). formed with HP-β-CD demonstrates superior stability water compared those β-CD DM-β-CD. preparation process for was optimized through an orthogonal testing approach. optimal conditions were determined mass ratio 1:125, time 2 h, temperature 30 °C. confirmed using DSC, Fourier Transform Infrared FTIR, XRD techniques. vitro tests indicated that 2.9 times greater than Molecular dynamics (MD) simulations provided insights into stabilize their solubility. primary force identified as van der Waals force.

Language: Английский

Citations

0
Lipid core-chitosan shell hybrid nanoparticles for enhanced oral bioavailability of sorafenib DOI

Najam-us Sahar,

Maleeha Gul,

Ho-Ik Choi

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 140030 - 140030

Published: Jan. 21, 2025

Language: Английский

Citations

0
Development and preclinical evaluation of a lipomer-based combinatorial delivery system for phytoconstituent and immunosuppressant in the management of Rheumatoid arthritis DOI

Shriya Karmarkar,

Gaurav Pandey,

Sankalp Gharat

et al.

Particulate Science And Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: March 15, 2025

Language: Английский

Citations

0
Development of Etoricoxib loaded mesoporous silica nanoparticles laden gel as vehicle for transdermal delivery: Optimization, ex-vivo permeation, histopathology and in-vivo anti-inflammatory study. DOI
Dibyalochan Mohanty,

N. G. Divya,

Ameeduzzafar Zafar

et al.

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: April 7, 2025

Etoricoxib (ETB) is a nonsteroidal anti-inflammatory therapeutic agent. It poorly soluble and has various gastrointestinal side effects such as bleeding ulcers after oral administration. The present research aimed to develop an ETB-loaded mesoporous silica nanoparticle-laden gel (ETB-MSNPs) for transdermal delivery improve efficacy. ETB-MSNPs were synthesized using precipitation solvent evaporation technique their optimization was performed Box-Behnken design. optimized incorporated into carbopol-chitosan evaluated in-vitro, ex-vivo, in-vivo activity. displayed nanosize of particles with distribution high entrapment efficiency ETB. FTIR DSC studies showed that ETB encapsulated in MSNPs. successfully integrated the carbopol chitosan gel, which exhibited excellent viscosity spreadability. significantly higher more sustained release compared pure gel. Optimized considerably effect significant reduction IL-1β TNF-α levels histopathological examination confirmed did not exhibit any toxicity on skin. Based findings, results suggest MSNPs potential carrier enhancing efficacy through topical delivery, although further are needed fully confirm its effectiveness.

Language: Английский

Citations

0