Targeted knockout and plasmid-based transfer of NRPS/PKS for improving lipopeptide iturin A synthesis

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 302, P. 140610 - 140610

Published: Feb. 2, 2025

Language: Английский

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Porous poly (lactic-co-glycolic acid) microspheres loaded with neutral and acidic ginseng polysaccharides ameliorate pneumonia in mice

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123697 - 123697

Published: May 1, 2025

Language: Английский

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Lactobacilli-Mediated Regulation of the Microbial–Immune Axis: A Review of Key Mechanisms, Influencing Factors, and Application Prospects

Foods, Journal Year: 2025, Volume and Issue: 14(10), P. 1763 - 1763

Published: May 16, 2025

Lactobacilli, as the main member of food microorganisms, is an important component intestinal microbial community and plays crucial roles in regulating immune capacity body. This review provides a comprehensive exploration key components Lactobacilli-mediated regulation effects, including immunogenic (peptidoglycan lipoteichoic acid) metabolites (short-chain fatty acids, bacteriocins, exopolysaccharides), which can interact with host cell receptors to initiate complex signaling pathways. In addition, immunomodulatory activity be influenced by multiple factors species differences, host-related (age, physiological conditions, gut microbiota), environmental (nutrient substrates, temperatures, etc.), application strategies precision probiotic development, gene-editing driven engineering, nanocarrier systems have also been proposed enhance potential. Finally, this theoretical basis for intervention immune-related diseases offers prospects applications pharmaceutical industries.

Language: Английский

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Immunoregulatory Effects of Codonopsis pilosula Polysaccharide Modified Selenium Nanoparticles on H22 Tumor-Bearing Mice

Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4073 - 4073

Published: Dec. 17, 2024

Codonopsis pilosula polysaccharide (CPP) and rare element selenium (Se) have been proved to exert various biological activities, our previous study demonstrated that nanoparticles modified with CPP (CPP-SeNPs) possessed significantly enhanced tumor cytotoxicity in vitro. This aimed investigated the inhibitory effects of CPP-SeNPs complex on H22 solid tumors via immune enhancement. In this study, tumor-bearing mice model was constructed, potential mechanisms antitumor were further explored by evaluating cytokines expression levels, cells activities apoptotic indicators each group. The results effectively exerted dose-dependent protective organs vivo, leading increase peripheral white blood cell counts inhibition growth rate 47.18% high-dose group (1.5 mg/kg). Furthermore, treatment elevated levels TNF-α, IFN-γ, IL-2 sera, NK cytotoxicity, augmented macrophage phagocytosis capacity, as well increased both amounts proliferation activity lymphocyte subsets. improved system’s ability clear up-regulating Bax while down-regulating Bcl-2 within tumors, indicating activation mitochondrial apoptosis pathway. Therefore, administration can inhibit enhancing response mice, which might be relevant regulation gut microbiota short-chain fatty acids metabolisms. These findings could provide theoretical support data foundation for development functional food drug adjuvants.

Language: Английский

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Preliminary characterization of Ramaria botrytoides polysaccharide RB-P1-1 and analysis of its hypoglycemic effects by altering the gut microbiota and metabolites in mice with type 2 diabetes mellitus

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138774 - 138774

Published: Dec. 1, 2024

Language: Английский

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