Emerging Approaches in Glioblastoma Treatment: Modulating the Extracellular Matrix Through Nanotechnology

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 142 - 142

Published: Jan. 21, 2025

Glioblastoma’s (GB) complex tumor microenvironment (TME) promotes its progression and resistance to therapy. A critical component of TME is the extracellular matrix (ECM), which plays a pivotal role in promoting tumor’s invasive behavior aggressiveness. Nanotechnology holds significant promise for GB treatment, with potential address challenges posed by both blood-brain barrier ECM. By enabling targeted delivery therapeutic diagnostic agents, nanotechnology offers prospect improving treatment efficacy accuracy at site. This review provides comprehensive exploration GB, including epidemiology, classification, current strategies, alongside intricacies TME. It highlights nanotechnology-based focusing on nanoparticle formulations such as liposomes, polymeric nanoparticles, gold have shown Furthermore, it explores how different emerging strategies modulate ECM overcome high density, restricts drug distribution within tumors. emphasizing intersection ECM, this underscores an innovative approach advancing treatment. addresses limitations therapies, identifies new research avenues, emphasizes improve patient outcomes.

Language: Английский

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Research Progress on Clinical Markers of Atrial Cardiomyopathy

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 1588 - 1594

Published: Jan. 1, 2025

Language: Английский

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HIV-associated neurocognitive disorders (HAND): Optimal diagnosis, antiviral therapy, pharmacological treatment, management, and future scopes

Journal of the Neurological Sciences, Journal Year: 2025, Volume and Issue: 470, P. 123410 - 123410

Published: Jan. 29, 2025

Language: Английский

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Repetitive Low-Level Blast Exposure Alters Circulating Myeloperoxidase, Matrix Metalloproteinases, and Neurovascular Endothelial Molecules in Experienced Military Breachers

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1808 - 1808

Published: Feb. 20, 2025

Repeated exposure to low-level blast overpressure, frequently experienced during explosive breaching and heavy weapons use in training operations, is increasingly recognised as a serious risk the neurological health of military personnel. Although research on underlying pathobiological mechanisms humans remains limited, this study investigated effects such circulating molecular biomarkers associated with inflammation, neurovascular damage, endothelial injury. Blood samples from breachers were analysed for myeloperoxidase (MPO), matrix metalloproteinases (MMPs), junctional proteins indicative blood-brain barrier (BBB) disruption including occludin (OCLN), zonula occludens-1 (ZO-1), aquaporin-4 (AQP4), syndecan-1 (SD-1). The results revealed significantly elevated levels MPO, MMP-3, MMP-9, MMP-10 compared unexposed controls, suggesting heightened oxidative stress, vascular Increased OCLN SD-1 further indicated BBB glycocalyx degradation breachers. These findings highlight potential chronic unit damage/dysfunction repeated underscore importance early targeted interventions-such reducing reinforcing integrity, managing inflammation-that could be essential mitigating long-term impairment exposure.

Language: Английский

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Decoding the Nectin Interactome: Implications for Brain Development, Plasticity, and Neurological Disorders

ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 2, 2025

The nectin family of cell adhesion molecules (CAMs) comprising nectins and nectin-like has emerged as a key regulator various pivotal neural processes, including neuronal development, migration, synapse formation, plasticity. Nectins engage in homophilic heterophilic interactions to mediate cell-cell adhesion, contributing the establishment maintenance circuits. Their extracellular domains facilitate trans-synaptic interactions, while intracellular participate signaling cascades influencing cytoskeletal dynamics synaptic function. exhibition distinct localization patterns neurons, astrocytes, blood-brain barrier underscores their diverse roles brain. dysregulation been implicated several neurological disorders, such neurodevelopmental depression, schizophrenia, Alzheimer's disease. This review examines structural functional characteristics distribution molecular mechanisms governing connectivity cognition. It further discusses experimental studies unraveling nectin-mediated pathophysiology potential therapeutic interventions targeting nectin-related pathways. Collectively, this comprehensive analysis highlights significance brain function, paving way for future research directions clinical implications.

Language: Английский

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Bacterial meningitis is a significant catalyst for neuroinflammation

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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