Published: Jan. 1, 2024
Language: Английский
Published: Jan. 1, 2024
Language: Английский
LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117690 - 117690
Published: March 1, 2025
Language: Английский
Citations
0ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 10, 2025
The complex molecular mechanisms involving genetic and epigenetic modifications contribute to colorectal cancer (CRC), which remains a significant threat world health. This review elucidates the role of proteomics genomics in progression, diagnosis, treatment cancers. All potential key pathways involved CRC, including WNT, MAPK, PI3K, TGF-β pathways, are reviewed with systematic analysis, concluding their involvement tumorigenesis therapeutic resistance. Emerging next-generation sequencing technologies revealed critical mutations that relevant CRC development. Proteomics has contributed identifying biomarkers post-translational hold promise for targeted therapies. Recent technological advances have provided functional insights into protein signaling networks through mass spectrometry integrated proteogenomic approaches. work emphasizes biomarker-driven translational efforts integrate genomic expression profiles refine personalized treatments. application innovations liquid biopsy computational biology advocates precision medicine paths improve outcomes CRC. Now, pharmacoproteomics offers novel domains drug discovery resistance management serves as foundation comprehensive paradigms.
Language: Английский
Citations
0Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 2
Published: Nov. 18, 2024
Language: Английский
Citations
0Published: Jan. 1, 2024
Language: Английский
Citations
0