Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4073 - 4073

Published: Dec. 17, 2024

Codonopsis pilosula polysaccharide (CPP) and rare element selenium (Se) have been proved to exert various biological activities, our previous study demonstrated that nanoparticles modified with CPP (CPP-SeNPs) possessed significantly enhanced tumor cytotoxicity in vitro. This aimed investigated the inhibitory effects of CPP-SeNPs complex on H22 solid tumors via immune enhancement. In this study, tumor-bearing mice model was constructed, potential mechanisms antitumor were further explored by evaluating cytokines expression levels, cells activities apoptotic indicators each group. The results effectively exerted dose-dependent protective organs vivo, leading increase peripheral white blood cell counts inhibition growth rate 47.18% high-dose group (1.5 mg/kg). Furthermore, treatment elevated levels TNF-α, IFN-γ, IL-2 sera, NK cytotoxicity, augmented macrophage phagocytosis capacity, as well increased both amounts proliferation activity lymphocyte subsets. improved system’s ability clear up-regulating Bax while down-regulating Bcl-2 within tumors, indicating activation mitochondrial apoptosis pathway. Therefore, administration can inhibit enhancing response mice, which might be relevant regulation gut microbiota short-chain fatty acids metabolisms. These findings could provide theoretical support data foundation for development functional food drug adjuvants.

Language: Английский