Comparative evaluation of gastrointestinal delivery vehicles for high-activity complexes from Sporidiobolus pararoseus and their application in colonic fermentation

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106700 - 106700

Published: April 1, 2025

Language: Английский

Nicotinamide Mononucleotide Alleviates Bile Acid Metabolism and Hormonal Dysregulation in Letrozole-Induced PCOS Mice

Biology, Journal Year: 2024, Volume and Issue: 13(12), P. 1028 - 1028

Published: Dec. 8, 2024

Polycystic ovary syndrome (PCOS) involves complex genetic, metabolic, endocrine, and environmental factors. This study explores the effects of nicotinamide mononucleotide (NMN) in a letrozole-induced PCOS mouse model, focusing on metabolic regulation. Letrozole-induced aromatase inhibition elevated androgen reduced bile acid levels, linking liver dysfunction gut imbalance to PCOS. Letrozole-treated mice exhibited disrupted estrous cycles, ovarian congestion, testosterone. NMN intervention alleviated hyperandrogenism, abnormalities, decline but did not fully restore cycle or improve lipid profiles. Metabolomic analysis showed that partially reversed metabolism disturbances. These findings highlight NMN’s protective role reducing hyperandrogenism cyst formation. However, effective treatment should target metabolism, just symptoms, mitigate systemic effects. Bile dysregulation may play key progression warrants further investigation.

Language: Английский

Comparative Evaluation of Gastrointestinal Delivery Vehicles for High-Activity Complexes from Sporidiobolus Pararoseus and Their Application in Colonic Fermentation

Published: Jan. 1, 2024

Language: Английский