Exosome-Loaded GelMA Hydrogel as a Cell-Free Therapeutic Strategy for Hypertrophic Scar Inhibition DOI Creative Commons
Hui Wang, Xiugong Gao, Yanxia Zhao

et al.

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2025, Volume and Issue: Volume 18, P. 1137 - 1149

Published: May 1, 2025

Language: Английский

Recent advances in hyaluronic acid-based hydrogels for diabetic wound healing DOI
Chenguang Liu,

Ronger Ai,

Bi-zhi Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140797 - 140797

Published: Feb. 7, 2025

Language: Английский

Citations

1
Mesenchymal stem cells from perinatal tissues promote diabetic wound healing via PI3K/AKT activation DOI Creative Commons
Jiawei Huang, Qing Deng,

Lai Ling Tsang

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 8, 2025

Abstract Background Diabetic foot ulcers (DFUs) represent a major complication of diabetes, often leading to poor healing outcomes with conventional treatments. Mesenchymal stem cell (MSC) therapies have emerged as promising alternative, given their potential modulate various pathways involved in wound healing. This study evaluates and compares the therapeutic MSCs derived from perinatal tissues—human umbilical cord (hUCMSCs), human chorionic villi (hCVMSCs), decidua basalis (hDCMSCs)—in diabetic model. Methods We performed vitro vivo studies compare efficacy hUCMSCs, hCVMSCs, hDCMSCs. Mass spectrometry was used analyze secreted proteins MSCs. incorporated into polyethylene glycol diacrylate (PEGDA) sodium alginate (SA) hydrogel matrix collagen I (Col-I) evaluate effects on Results All three types promoted healing, hUCMSCs hCVMSCs showing stronger compared Both demonstrated robust kinetics, enhanced keratinocyte proliferation (KRT14 + /Ki67 cells), maturation (KRT10/KRT14 ratio), angiogenesis. In that MSC-derived secretome migration, endothelial function recruitment, indicating paracrine effects. revealed conserved set including THBS1 (thrombospondin 1), SERPINE1 (serpin family E member ANXA1 (annexin A1), LOX (lysyl oxidase), ITGB1 (integrin beta-1) which are extracellular (ECM) organization PI3K/AKT signaling pathway playing central role. The PEGDA/SA/Col-I unique balance mechanical biological properties an optimal environment for MSC viability function. Application either hUCMSC- or hCVMSC-laden hydrogels resulted accelerated closure, improved re-epithelialization, increased deposition, vascularization vivo. Conclusions From tissues particularly significantly enhance through activation while hDCMSCs exhibited weaker efficacy. supports offering scaffold DFU treatment. These findings underscore specific optimized formulations advancing care.

Language: Английский

Citations

1
State-of-the-art in natural hydrogel-based wound dressings: Design, functionalization, and fabrication approaches DOI Creative Commons
Hossein Baniasadi

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 342, P. 103527 - 103527

Published: April 25, 2025

Language: Английский

Citations

0
Selenide-modified hyaluronic acid hydrogel promotes scleral remodeling during the recovery phase of form-deprivation myopia by inhibiting HIF-1α-mediated inflammation DOI
Lihua Zhao, Zhou Yang, Zhenyu Jiang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143385 - 143385

Published: April 1, 2025

Language: Английский

Citations

0
Exosome-Loaded GelMA Hydrogel as a Cell-Free Therapeutic Strategy for Hypertrophic Scar Inhibition DOI Creative Commons
Hui Wang, Xiugong Gao, Yanxia Zhao

et al.

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2025, Volume and Issue: Volume 18, P. 1137 - 1149

Published: May 1, 2025

Language: Английский

Citations

0