Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications
Discover Materials,
Journal Year:
2025,
Volume and Issue:
5(1)
Published: Jan. 9, 2025
Achieving
the
ideal
replacement
for
robust
biological
tissues
requires
biocompatible
materials
with
a
nuanced
blend
of
characteristics,
including
organ
specific
toughness,
durability,
self-repairing
capability,
and
well-defined
structure.
Hydrogels,
structured
high
water
containing
3D-crosslinked
polymeric
networks,
present
promising
avenue
in
biomedical
applications
due
to
their
close
resemblance
natural
tissues.
However,
mechanical
performance
often
falls
short,
limiting
clinical
applications.
Recent
research
has
been
focused
on
developing
hydrogel
therapeutic
advancements
have
spurred
researchers
develop
hydrogels
having
acceptable
toughness.
While
it
is
now
possible
tailor
properties
synthetic
gels
mimic
those
tissues,
critical
aspects
such
as
biocompatibility
crosslinking
strategies
are
frequently
neglected.
This
review
scrutinizes
structural
techniques
designed
improve
toughness
hydrogels,
focusing
especially
innovative
efforts
integrate
these
enhancements
into
natural-based
hydrogels.
By
thoroughly
examining
methodologies,
sheds
light
complexities
strengthening
will
propose
valuable
insights
development
next-generation
tissue
substitutes.
Language: Английский
Rheological Behavior, Textural Properties, and Antioxidant Activity of Porphyra yezoensis Polysaccharide
Molecules,
Journal Year:
2025,
Volume and Issue:
30(4), P. 882 - 882
Published: Feb. 14, 2025
Porphyra
yezoensis
has
attracted
much
attention
due
to
its
gelling
properties
and
bioactivity.
In
this
study,
the
chemical
structure
of
polysaccharides
(PYPSs)
was
characterized,
effects
concentration,
temperature,
pH,
calcium
ion
(Ca2+)
addition
on
rheological
PYPS
were
systematically
investigated.
Chemical
composition
analysis
indicated
that
primarily
contained
galactose
(89.76%)
sulfate
(15.57%).
Rheological
tests
demonstrated
exhibited
typical
pseudoplastic
properties,
with
apparent
viscosity
increasing
an
concentration.
Temperature
elevation
from
30
°C
90
weakened
intermolecular
forces
reduced
viscosity,
whereas
neutral
pH
(7.0)
provided
optimal
electrostatic
equilibrium
maintain
highest
viscosity.
Ca2+
could
modulate
interactions
between
molecules
affect
formation
gel
network
structure.
When
concentration
reached
value
6
mM,
bridges
formed
not
only
enhanced
behavior
textural
but
also
a
smooth
well-ordered
structure,
achieving
fractal
dimension
(Df
=
2.9600),
though
excessive
disrupted
Furthermore,
possessed
significant
scavenging
ability
against
DPPH,
ABTS,
HO•
radicals,
demonstrating
potential
application
as
natural
antioxidant
in
functional
foods.
Language: Английский
Advancing Gel Systems with Natural Extracts: Antioxidant, Antimicrobial Applications, and Sustainable Innovations
Gels,
Journal Year:
2025,
Volume and Issue:
11(2), P. 125 - 125
Published: Feb. 8, 2025
The
integration
of
natural
extracts
into
gel
systems
has
emerged
as
a
transformative
approach
to
enhance
functional
properties,
including
antioxidant,
antimicrobial,
and
therapeutic
effects.
This
review
underscores
the
remarkable
potential
extract-enriched
gels,
which
effectively
combine
sustainability
with
improved
functionality.
These
bioactive
compounds,
sourced
from
plants
animals,
encompass
polyphenols,
flavonoids,
essential
oils,
chitosan,
proteins,
polysaccharides.
They
provide
an
eco-friendly
alternative
synthetic
additives
find
applications
across
various
sectors,
pharmaceuticals,
cosmetics,
food
packaging.
Despite
their
promise,
challenges
remain,
such
variability
in
extract
composition,
stability
scalability
for
industrial
use.
To
address
these
issues,
innovative
strategies
like
nanoencapsulation,
responsive
hydrogels,
AI-driven
optimization
have
demonstrated
significant
progress.
Additionally,
emerging
technologies,
3D
printing
adherence
circular
economy
principles,
further
versatility,
efficiency,
systems.
By
integrating
advanced
tools
methodologies,
enriched
are
well-positioned
meet
contemporary
consumer
demands
multifunctional
products.
innovations
not
only
improve
performance
but
also
align
global
goals,
setting
stage
widespread
adoption
continued
development
fields.
Language: Английский
Tough and swelling-resistant gellan gum-based biofilms with excellent transparency, surface hydrophobicity and barrier capability
Yong Deng,
No information about this author
Panpan Li,
No information about this author
Yudong Lian
No information about this author
et al.
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
308, P. 142763 - 142763
Published: April 4, 2025
Language: Английский
Degradable Alginate Hydrogel Intervention Catheters with Gradient Hardness in Length
Bingbing Yang,
No information about this author
Weinan Gu,
No information about this author
Jie Pan
No information about this author
et al.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 27, 2025
Abstract
Interventional
catheter,
a
medical
device
characterized
by
gradient
hardness
from
one
end
to
the
other,
exhibits
enhanced
flexibility
upon
insertion
into
human
body.
This
unique
configuration
accommodates
various
anatomical
structures
and
surgical
requirements.
study
reports,
for
first
time,
degradable
hydrogel
interventional
catheter
with
hardness.
A
novel
aqueous
reaction
methodology
is
developed,
enabling
direct
transformation
of
solid
sodium
alginate
(SA)
film
strip
hollow
catheter.
process
involves
copper
ions‐induced
asymmetry
crosslinking
in
an
solution,
solvent
exchange
ethanol,
removal
ions
ethylenediaminetetraacetic
acid,
subsequent
bimetallic
CaCl
2
FeCl
3
solutions.
method
results
gradient‐hardness
catheters
without
surface
defects
such
as
protrusions
pits.
The
demonstrates
robustness
mechanical
strength
reaching
5.5
MPa
soft
head
28
hard
tail.
By
incorporating
gradual
stiffness
variation,
superior
lubricity
more
effectively
adapts
body,
potentially
minimizing
tissue
damage
expediting
procedures.
Consequently,
it
shows
significant
potential
Language: Английский
Advances in Cellulose-Based Hydrogels: Current Trends and Challenges
Gels,
Journal Year:
2024,
Volume and Issue:
10(12), P. 842 - 842
Published: Dec. 20, 2024
This
paper
provides
a
solid
foundation
for
understanding
the
synthesis,
properties,
and
applications
of
cellulose-based
gels.
It
effectively
showcases
potential
these
gels
in
diverse
applications,
particularly
biomedicine,
highlights
key
synthesis
methods
properties.
However,
to
push
field
forward,
future
research
should
address
gaps
environmental
impact,
mechanical
stability,
scalability
gels,
while
also
considering
how
overcome
barriers
their
industrial
use.
will
ultimately
allow
realization
large-scale,
sustainable
applications.
Language: Английский