Advances in the application of natural/synthetic hybrid hydrogels in tissue engineering and delivery systems: A comprehensive review

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 672, P. 125323 - 125323

Published: Feb. 7, 2025

Language: Английский

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New Dawn in the Treatment of Rheumatoid Arthritis: Advanced Insight into Polymer Hydrogel Research

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 136 - 136

Published: Feb. 15, 2025

As a chronic systemic autoimmune disease, rheumatoid arthritis (RA) not only damages joints and other organs or systems throughout the body but also torments patients' physical mental health for long time, seriously affecting their quality of life. According to incomplete statistics at present, global prevalence RA is approximately 0.5-1%, number patients increasing year by year. Currently, drug therapies are usually adopted treatment RA, such as non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic (DMARDs), glucocorticoids/steroids, so on. However, traditional therapy has problems half-lives, cycles requiring frequent administration, lack specificity, possible adverse reactions (such gastrointestinal side effects, skin stratum corneum barrier damage, toxicity), which greatly restrict RA. In order improve limitations drug, physical, surgical treatments large related studies on have been carried out. Among them, hydrogels widely used in research due excellent biocompatibility, mechanical properties, general adaptability. For example, can be injected into synovial cavity fluid reduce wear between joints, lubricate avoid surface degradation. This article reviews applications under different functions situation carriers through delivery routes confirms outstanding potential great significance.

Language: Английский

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A Comprehensive Review on Protein‐Based Hydrogels: From Structure Modification to Applications

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(14)

Published: April 1, 2025

Abstract Protein‐based hydrogels have been widely used in the biomedical field since their good biocompatibility and adjustable physical properties, which are also similar to natural extracellular matrix. However, fragile mechanical properties single function of protein limited application. Usually, chemical modification proteins combination with other biological materials strategies improve performance hydrogels. This review first focused on method then introduced kinds protein‐based detail. In addition, we summarized applications drug delivery, wound dressing, tissue engineering, 3D printing, biosensors. Finally, highlighted challenges future prospects hydrogels, may provide a reference for design novel multifunctional

Language: Английский

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Characterization of Biopolymer Hydrogels Prepared with Water Exposed to Indirect Plasma Treatment

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13427 - 13427

Published: Dec. 14, 2024

This study aimed to evaluate the influence of indirect-plasma-treated water (IPTW) in preparation hydrogels. Three commonly used natural, biodegradable polymers with ability form gels were selected: gelatin, carrageenan, and sodium alginate. The pH, gelling temperature, texture profile, swelling degree, color hydrogels evaluated, subjected Fourier-transform infrared (FTIR) spectroscopy. morphology was investigated using Scanning Electron Microscopy (SEM). Additionally, physiochemical properties media, which distilled (DW) IPTW, analyzed. results indicated that prepared IPTW characterized by a lower higher hardness gelation temperature. After 48 h ratio (SR) testing, gelatin alginate made SR, while an inverse relationship found case SR carrageenan gels. FTIR analysis confirmed changes binding ability. use also significantly affected microstructure tested materials. A statistically significant change gel samples noted. showed induces physicochemical hydrogels, can lead enhancement their practical applications.

Language: Английский

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