Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3807 - 3807
Published: Nov. 6, 2024
Deer bone is rich in proteins and free amino acids, offering high nutritional value benefits such as strengthening bones antioxidant properties. However, the development utilization of deer resources are limited, safety evaluation health foods incomplete.
Language: Английский
Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(2)
Published: April 1, 2025
Language: Английский
Citations
5
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 2557 - 2581
Published: Feb. 1, 2025
Ulcerative colitis is a chronic intestinal disease linked to barrier damage, ferroptosis and dysbiosis. Coix lacryma-jobi natural food with food-medicine homology, whose seed-derived oil (Coix seed oil, CSO) has been shown anti-inflammatory activity in vitro. Here, the effects mechanisms of CSO on ulcerative (UC) vivo are systematically investigated. Firstly, UC mice was replicated by 3% DSS, assessed efficacy observing fecal occult blood, colon length, DAI score pathological histomorphological changes tissues. The barrier-protective were observed AB staining qRT-PCR. Secondly, biological targets obtained from TCMSP database Swiss Target Prediction database, downloaded FerrDb platform, UC-related GEO intersection above three taken obtain "CSO-UC-Ferroptosis" targets, which analysed GO KEGG enrichment, GSEA analysis, immune cell infiltration validation. Finally, core genes molecular docking potential active components CSO. In order further verify effect ferroptosis, GPX4 agonist RSL-3 used stimulate vivo, levels Iron, MDA SOD measured, immunohistochemistry detect tight junction proteins protein mice. Besides, evaluated intercellular junctions tissues each group under electron microscope. addition, 16sRNA sequencing performed contents observe flora improved physiological parameters, reduced inflammation response regulated restored gut microbiota balance Bioinformatics results showed that G6PD, ABCC1 at CSO, also demonstrated similar expression DSS-induced models vivo. Our findings demonstrate for first time ameliorated regulating mice, suggesting as promising candidate treatment warranting investigation.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141640 - 141640
Published: March 1, 2025
Language: Английский
Citations
1
Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149607 - 149607
Published: April 1, 2025
Language: Английский
Citations
1
World Journal of Diabetes, Journal Year: 2024, Volume and Issue: 16(1)
Published: Nov. 29, 2024
The onset and progression of type 2 diabetes mellitus (T2DM) are strongly associated with imbalances in gut bacteria, making the microbiome a new potential therapeutic focus. This commentary examines recent publication World Journal Diabetes . article explores association between T2DM microbiota, focus on pathophysiological changes related to dysbiosis. It proposes innovative microbiome-targeted strategies evaluates challenges future directions such approaches. editorial summarizes key points their discussion role elaborates influence specific microbial species disease through host–microbiota metabolic axis. provides insights for research gut-microbiota-based interventions T2DM.
Language: Английский
Citations
5
World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(7)
Published: Jan. 18, 2025
Fungal esophagitis (FE) is caused by fungal invasion of the esophageal mucosa. Under endoscopy, mucosa shows edema, congestion, erosion, and ulceration, bleeds easily when touched, surface covered with small white spots like "bean curd residue". Clinical cases showing typical FE under endoscopic imaging but negative mucosal brush (referred to as suspected FE) have increased difficulty challenge clinical diagnosis treatment. At present, flora case has not been thoroughly studied. To characterize in FE, normal controls (NCs), identify marker species improve detection FE. This was a case-control study. A total 19 patients 16 10 NCs were selected endoscopy. The cell samples each group sequenced internal transcribed spacer (ITS) 1 analyzed bioinformatics. In patients, richness, diversity evenness, measured Chao1 index, Shannon index Pielou lower than NCs, comparison between most significant (P < 0.05). Compared relative abundance Candida significantly 0.001), while Yarrowia decreased Moreover, groups 0.001). area curve for 99.5% 0.05) 81.3% 0.05), respectively. Finally, compared Ascomycota decreased, Yarrowia, Thermomyces Pichia increased. ITS showed that composition community similar groups. can be used an auxiliary diagnostic method provide theoretical basis follow-up
Language: Английский
Citations
0
Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 537 - 537
Published: Feb. 6, 2025
Red yeast rice is a nutraceutical fermented product used worldwide for the symptomatic relief of dyslipidemia and cardiovascular disease. However, fermentation-induced lipid transformation from to red remains unclear. Herein, an ultra-high performance liquid chromatography coupled with hybrid quadrupole-orbitrap mass spectrometry method was developed comprehensive analysis during fermentation. A total 246 lipids fall in 21 subclasses were annotated rice, including 37 lysophospholipids, 14 phospholipids, 29 diglycerides, 114 triglycerides fatty acid (15 species), ceramide (12 hexosylceramide (3 sitosterol ester (2 monogalactosyldiacylglycerol digalactosyldiacylglycerol monogalactosylmonoacylglycerol (8 digalactosylmonoacylglycerol (5 coenzyme Q (1 acyl hexosyl campesterol acylcarnitine species). Results showed that profiles changed, new species emerged. Notably, 18 medium- long-chain triacylglycerols short-chains tentatively identified. These also show effects body fat accumulation reduction, hypolipidemic hypoglycemic activities. Furthermore, profoundly changed quantified, dynamic changes investigated. This study clarified molecular compositional aspect.
Language: Английский
Citations
0
Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111264 - 111264
Published: Feb. 1, 2025
Depression is a prevalent neuropsychiatric disorder characterized by persistent sadness and lack of interest, significantly impacting the quality life. Icaritin, bioactive compound from Herba Epimedii, which has antidepressant-like effects. However, potential target icaritin in brain, especially concerning transcription factors, not well understood. In this study, we demonstrated that ameliorated depressive-like behaviors chronic corticosterone (CORT)-induced mouse model. This study aimed to investigate role modulating activity cAMP-response element binding protein 1 (CREB1), crucial factor implicated neuronal function mood regulation. Through combination virtual screening molecular docking, identified CREB1 as intersections databases, leading selection 43 candidate compounds, among exhibited favorable docking score previously reported antidepressant Biolayer interferometry (BLI) analysis confirmed direct CREB1, with dissociation constant (KD) 7.02E-06 M. Further mutational revealed residues Q65 Q229 were essential for icaritin. Additionally, Quantitative Real-Time PCR (qRT-PCR) treatment upregulated mRNA levels genes hippocampus cortex. Bioinformatics indicated interacts several neuroprotective pathways, reinforcing its significance depression. conclusion, our findings suggest may represent promising therapeutic depression enhancing CREB1-mediated neuroprotection, warranting further investigation into clinical applications underlying mechanisms.
Language: Английский
Citations
0
Translational Oncology, Journal Year: 2025, Volume and Issue: 54, P. 102295 - 102295
Published: Feb. 26, 2025
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141575 - 141575
Published: Feb. 27, 2025
Language: Английский
Citations
0