Quantitative Analysis of Deer Bone Hydroethanolic Extract Using Label-Free Proteomics: Investigating Its Safety and Promoting Effect on Mouse Embryonic Osteoblastic Progenitor Cell Proliferation DOI Open Access
Y.-L. Li,

Junxia Ma,

Yu Jiang

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3807 - 3807

Published: Nov. 6, 2024

Deer bone is rich in proteins and free amino acids, offering high nutritional value benefits such as strengthening bones antioxidant properties. However, the development utilization of deer resources are limited, safety evaluation health foods incomplete.

Language: Английский

Structural characteristics of a polysaccharide isolated from Lactaruis volemus Fr. and its anti-diabetic effects regulated by the modulation of gut microbiota and metabolites DOI
Yanan Wang,

Xinyi Qian,

Lingzhi Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142294 - 142294

Published: March 1, 2025

Language: Английский

Citations

0
Immune Restoration Mechanism Analysis of Akkermansia PROBIO in Mice Treated with Cyclophosphamide through Re-balancing Microbiota Composition DOI
Junpeng Zhang, Xin Ma, Wenjiao Du

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106450 - 106450

Published: March 1, 2025

Language: Английский

Citations

0
Multiomics comparative analysis reveals the role of carbon metabolism in enhancing monascin and ankaflavin production in Monascus purpureus DOI Creative Commons
Leyuan Li, Lili Zhu, Xiaoqian Liu

et al.

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 228, P. 120938 - 120938

Published: March 31, 2025

Language: Английский

Citations

0
Structure, Function, Synthesis and Improved Strategies of Fucosylated Human Milk Oligosaccharides and Their Future Perspectives: A Review DOI

Ya-Ya Yang,

Shunli Jing,

Le Zhang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106584 - 106584

Published: April 1, 2025

Language: Английский

Citations

0
Physicochemical characterization and evaluation of the antioxidant potential of water-soluble polysaccharides from red microalgae, Rhodomonas salina DOI Creative Commons

Farjana Akter,

Lakshmi Krishnan, Gemma Mestres

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143417 - 143417

Published: April 1, 2025

Language: Английский

Citations

0
Physicochemical Characterization, Metabolite Profiling, and Preclinical Pharmacokinetic Assessment of a Sulfonamide‐Based Pyruvate Kinase M2 Activator for Anticancer Lead Identification DOI
Rudradip Das, Niraj Rajput, S. K. Sharma

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(16)

Published: April 1, 2025

Abstract This study investigates the pharmacokinetic, physicochemical, and metabolite properties of 9b , a novel imidazopyrimidine‐based sulfonamide previously shown to be effective against A549 lung adenocarcinoma cell line. Aiming evaluate its ADME (absorption, distribution, metabolism, excretion) characteristics for drug development, found that possesses favorable physicochemical properties, including pKa 12.35, LogP 2.89, LogD 0.98. Stability tests demonstrated remains stable in human plasma liver microsomes up 1 h, with moderate protein binding (46%). Metabolite profiling using LC/Q‐TOF MS revealed three major metabolites ( M1 M2 M3 ), whereas vivo pharmacokinetic analysis via LC/QQQ‐MS indicated optimal parameters, C max T AUC, half‐life (t 1/2 ) consistent balanced profile. These results highlight ’s promising stability, binding, metabolic profile, positioning it as strong candidate further development an anticancer drug. Given impressive efficacy cancer lines, shows significant potential advancing treatment.

Language: Английский

Citations

0
Type 3 resistant starch prepared from jackfruit alleviated the hyperlipidemia via gut microbiota regulation DOI
Yutong Zhang, Jingyi Liu,

Xiaoai Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143452 - 143452

Published: April 1, 2025

Language: Английский

Citations

0
Rehmannia glutinosa polysaccharides alleviate cyclophosphamide-induced immunosuppression by enhancing immunity and restoring intestinal homeostasis DOI
Lin Yu,

Xiaofeng Shi,

Xuanqi Lu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 143692 - 143692

Published: April 30, 2025

Language: Английский

Citations

0
Effects of Rehmanniae Radix Praeparata polysaccharides on LPS-induced immune activation in mice based on gut microbiota, metabolomics and transcriptomics DOI

Wensen Zhang,

Na Cui,

Fazhi Su

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 143981 - 143981

Published: May 7, 2025

Language: Английский

Citations

0
Quantitative Analysis of Deer Bone Hydroethanolic Extract Using Label-Free Proteomics: Investigating Its Safety and Promoting Effect on Mouse Embryonic Osteoblastic Progenitor Cell Proliferation DOI Open Access
Y.-L. Li,

Junxia Ma,

Yu Jiang

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3807 - 3807

Published: Nov. 6, 2024

Deer bone is rich in proteins and free amino acids, offering high nutritional value benefits such as strengthening bones antioxidant properties. However, the development utilization of deer resources are limited, safety evaluation health foods incomplete.

Language: Английский

Citations

1