Fenton Reaction-Driven Oxidative Modification of Natural Polysaccharides: Insights and Innovations on Properties

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104866 - 104866

Published: Jan. 1, 2025

Language: Английский

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Structure–Antioxidant Activity Relationship of Polysaccharides Isolated by Microwave/Ultrasonic-Assisted Extraction from Pleurotus ferulae

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 91 - 91

Published: Jan. 14, 2025

To investigate the structure-antioxidant activity relationship, Pleurotus ferulae polysaccharides were extracted using ultrasonic (U-PFPS) and microwave/ultrasonic-assisted methods (MU-PFPS). Compared to U-PFPS with a molecular weight of 1.566 × 103 kDa, MU-PFPS exhibited lower 89.26 kDa. In addition, unlike U-PFPS, which is primarily composed glucose (Glu:Man:Gal = 91.1:3.5:5.4), has more balanced composition Glu:Man:Gal in ratio 39.4:27.8:32.8 contains branched chains. Furthermore, antioxidant analysis revealed that high concentration (at concentrations above 600 μg/mL) demonstrated stronger protective effects against oxidative damage RAW264.7 cells than did. Collectively, these data suggest higher branching degree at appropriate may correlate enhanced enzyme activities. Our work provides method for isolating offers insights into structure-activity relationship polysaccharides, laying foundation future applications polysaccharide modification structural characterization.

Language: Английский

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Application prospect of polysaccharide in the development of vaccine adjuvants

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 297, P. 139845 - 139845

Published: Jan. 15, 2025

Language: Английский

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Ruditapes philippinarum Polysaccharide Alleviates Hyperglycemia by Modulating Gut Microbiota in a Mouse Model of Type 2 Diabetes Mellitus

Molecular Nutrition & Food Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

ABSTRACT Type 2 diabetes mellitus (T2DM), a widespread chronic metabolic disorder, presents global challenge. Metformin hydrochloride, although widely prescribed, is associated with notable side effects. This study aims to explore safer, more effective alternatives by assessing the impact of Ruditapes philippinarum polysaccharides (RPPs) on glycemic control and modulation microbiota in T2DM mice. A mouse model was established through high‐sucrose/high‐fat diet intraperitioneal streptozotocin injection. Glycometabolism indicators, histopathological features, gut composition caecum samples were assessed. Following 4 weeks RPPs intervention, fasting blood glucose (FBG), glycated serum protein (GSP), area under curve (AUC) oral tolerance test (OGTT), total cholesterol (TC), triglyceride (TG), low‐density lipoprotein (LDL‐c) levels reduced mice, while AKT‐1 GLUT‐2 transcription significant increased. Short‐chain fatty acids (SCFAs) concentrations notably increased RPP‐L group compared Model group, improvements also observed medium‐chain (MCFAs) secondary bile (SBAs). Regarding microbiota, Firmicutes‐to‐Bacteroidetes (F/B) ratio substantially lower than group. At genus level, beneficial bacteria, such as Akkermansia , Alloprevotella Tidjanibacter Faecalibaculum demonstrated abundance. Correlation analysis identified Muribaculum Paramuribaculum Lacrimispora Turicibacter microbial taxa progression. significantly alleviated hyperglycemic symptoms mice enhancing presence leading marked improvement intestinal composition. research offers foundational insights for potential use R. biomedical nutraceutical applications.

Language: Английский

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A glucomannan from defatted Ganoderma lucidum spores: structural characterization and immunomodulatory activity via activating TLR4/MyD88/NF-κB signaling pathway

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139195 - 139195

Published: Dec. 1, 2024

Language: Английский

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