An injectable, self-healing, anti-infective, and anti-inflammatory novel glycyrrhizic acid hydrogel for promoting acute wound healing and regeneration
Q. J. Guo,
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Ruojing Li,
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Yeying Zhao
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et al.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
12
Published: Jan. 10, 2025
Bacterial
infection,
a
complex
wound
microenvironment,
and
persistent
inflammatory
response
in
acute
wounds
can
result
delayed
healing
abnormal
scar
formation,
thereby
compromising
the
normal
function
aesthetic
appearance
of
skin
tissue.
This
issue
represents
one
most
challenging
problems
clinical
practice.
study
aims
to
develop
hydrogel
dressing
specifically
designed
for
treatment
wounds,
providing
immediate
effective
protection
affected
areas.
innovation
seeks
offer
novel
advanced
solution
management
wounds.
In
this
study,
composite
scaffold
was
synthesized
through
reaction
between
oxidized
glycyrrhizic
acid
carboxymethyl
chitosan
Schiff
base.
The
material
properties
were
systematically
characterized,
its
biocompatibility
antibacterial
efficacy
rigorously
evaluated.
A
rat
model
established
compare
multiple
groups,
assessing
impact
on
microenvironment
repair.
results
demonstrated
that
OGA-CMCS
exhibited
excellent
injectability,
biocompatibility,
properties.
It
capable
enhancing
which
turn
influenced
polarization
macrophages
from
M1
M2
phenotype,
mitigating
response,
promoting
angiogenesis
granulation
tissue
regeneration,
accelerating
healing.
successfully
developed
glycyrrhizin-based
dressing,
not
only
introduces
innovative
approaches
emergency
surface
defects
but
also
provides
an
experimental
foundation.
is
anticipated
contribute
significantly
addressing
relevant
challenges.
Language: Английский
Construction of a methacrylated gelatine composite hydrogel based on tachyplesin II and its application in the repair of infected wounds
Colloids and Surfaces B Biointerfaces,
Journal Year:
2025,
Volume and Issue:
250, P. 114575 - 114575
Published: Feb. 18, 2025
Language: Английский
Injectable biocomposite cement: A dual-setting formula with magnesium potassium phosphate and κ-carrageenan hydrogel for orthopedic advancements
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
unknown, P. 137922 - 137922
Published: Nov. 1, 2024
Language: Английский
The novel cathelicidin-DM antimicrobial peptide conjugated carbomer and thermosensitive chitosan hydrogel speeds up wound-healing in both non-infected and S. aureus-infected wounds
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
288, P. 138659 - 138659
Published: Dec. 10, 2024
Language: Английский