New Dawn in the Treatment of Rheumatoid Arthritis: Advanced Insight into Polymer Hydrogel Research

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 136 - 136

Published: Feb. 15, 2025

As a chronic systemic autoimmune disease, rheumatoid arthritis (RA) not only damages joints and other organs or systems throughout the body but also torments patients' physical mental health for long time, seriously affecting their quality of life. According to incomplete statistics at present, global prevalence RA is approximately 0.5-1%, number patients increasing year by year. Currently, drug therapies are usually adopted treatment RA, such as non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic (DMARDs), glucocorticoids/steroids, so on. However, traditional therapy has problems half-lives, cycles requiring frequent administration, lack specificity, possible adverse reactions (such gastrointestinal side effects, skin stratum corneum barrier damage, toxicity), which greatly restrict RA. In order improve limitations drug, physical, surgical treatments large related studies on have been carried out. Among them, hydrogels widely used in research due excellent biocompatibility, mechanical properties, general adaptability. For example, can be injected into synovial cavity fluid reduce wear between joints, lubricate avoid surface degradation. This article reviews applications under different functions situation carriers through delivery routes confirms outstanding potential great significance.

Language: Английский

Low‐Crosslinked Hydrophilic Decellularized Adipose Matrix Hydrogels Achieve Efficient and Functional Xenotransplant Fat Regeneration by Optimizing Stem Cell Niche

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Xenogeneic decellularized adipose matrix(DAM) scaffolds are significant in soft tissue regeneration by addressing donor site morbidity and limited availability. However, natural DAM xenotransplantation remains unachieved. Previous efforts have relied on chemical modifications to reduce foreign body reactions, with inherent drawbacks outcomes. This study proposes a hydrogel scaffold that achieves efficient functional xenotransplant fat regeneration. Primarily, hydrophilic DAM(H‐DAM) is confirmed lower antigen content, but its regenerative potential constrained encapsulation impedes seed cell infiltration. Thus, H‐DAM prepared enhance the speed extent of It observed topological structure impacts infiltration, immune inflammatory response, Low‐crosslinked hydrogels emerged as optimal for adipogenic differentiation due loose networks degradation rates synchronizing Furthermore, wall‐like rather than filamentous provides superior niche stem engraftment activity. Finally, integrated multi‐omics data analysis demonstrated regenerated functionally mimics native tissue. These findings indicate xenogeneic gel support both structural reconstruction tissue, offering novel insights promising approach clinical translation DAM‐based therapies.

Language: Английский