Benzimidazole(s): synthons, bioactive lead structures, total synthesis, and the profiling of major bioactive categories DOI Creative Commons
Lotfi M. Aroua, Fahad M. Alminderej, Hind R. Almuhaylan

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(10), P. 7571 - 7608

Published: Jan. 1, 2025

Benzimidazole, a fused bicyclic compound with benzene and pentacyclic 1,3-diazole moeities, has simple aromatic heterocyclic structure. The moiety become an indispensable anchor for the development of new pharmacologically active products, yielded several therapeutic agents anticancer, antihypertensive, antimicrobial, antifungal antiulcer effects. Benzimidazoles, as synthetically feasible pharmacophoric synthons, have been relentlessly pursued preparation analogues derivatives, they successfully developed into some most sought-after vital pharmacophores drug discovery. use varied substituents differing patterns around benzimidazole nucleus provided wide spectrum biological activities. In addition, constitutes building block production drugs, candidates, chemical entities, lead molecules. importance this bioactivity, e.g., antibacterial, antitubercular, antidiabetic, antifungal, anti-inflammatory, analgesic, antioxidant, antihistaminic, antimalarial activity, led us to take note provide overview synthetic approaches various derivatives together their actions. This review is projected further assist in design benzimidazole-based compounds optimized products towards drug-development strategies.

Language: Английский

Benzimidazole(s): synthons, bioactive lead structures, total synthesis, and the profiling of major bioactive categories DOI Creative Commons
Lotfi M. Aroua, Fahad M. Alminderej, Hind R. Almuhaylan

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(10), P. 7571 - 7608

Published: Jan. 1, 2025

Benzimidazole, a fused bicyclic compound with benzene and pentacyclic 1,3-diazole moeities, has simple aromatic heterocyclic structure. The moiety become an indispensable anchor for the development of new pharmacologically active products, yielded several therapeutic agents anticancer, antihypertensive, antimicrobial, antifungal antiulcer effects. Benzimidazoles, as synthetically feasible pharmacophoric synthons, have been relentlessly pursued preparation analogues derivatives, they successfully developed into some most sought-after vital pharmacophores drug discovery. use varied substituents differing patterns around benzimidazole nucleus provided wide spectrum biological activities. In addition, constitutes building block production drugs, candidates, chemical entities, lead molecules. importance this bioactivity, e.g., antibacterial, antitubercular, antidiabetic, antifungal, anti-inflammatory, analgesic, antioxidant, antihistaminic, antimalarial activity, led us to take note provide overview synthetic approaches various derivatives together their actions. This review is projected further assist in design benzimidazole-based compounds optimized products towards drug-development strategies.

Language: Английский

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