Exploring the Nutraceutical Potential of a Food–Medicine Compound for Metabolic-Associated Fatty Liver Disease via Lipidomics and Network Pharmacology

Foods, Journal Year: 2025, Volume and Issue: 14(7), P. 1257 - 1257

Published: April 3, 2025

Metabolic-associated fatty liver disease (MAFLD) is a prevalent global health issue closely tied to dietary habits, impacting significant portion of the adult population. MAFLD linked various metabolic disorders, elevating risks cirrhosis and hepatocellular carcinoma severely patients' quality life. While therapeutic research has progressed, effective food-based interventions remain scarce. Natural products, rich in bioactive compounds offering benefits, have gained attention for their potential managing MAFLD. This study employed network pharmacology lipidomics investigate effects Food Medicine Homology (FMH) on using high-fat-diet-induced HepG2 cell model. We identified 169 components from Radix Puerariae, Hericium erinaceus, Rhizoma Curcumae longae, Camellia oleifera, Hoveniae Dulcis Semen, constructing drug-component-target that highlighted 34 key targets. The characteristic this FMH compound solution (HSD) were UPLC-QTOF-MS/MS. In vitro, HSD significantly reduced intracellular lipid accumulation, decreased inflammatory markers, mitigated hepatocyte damage. Lipidomics analysis revealed alterations metabolites, suggesting HSD's modulate sphingolipid glycerophospholipid metabolism, thus improving outcomes. underscores critical role complex modulating metabolism pathways, valuable insights developing FMH-based supplements functional foods alleviate By leveraging synergistic natural compounds, our findings hold implications innovative nutritional strategies disorder.

Language: Английский

Hericium erinaceus extract attenuates gastric mucosal injury via Nrf2/HO-1 pathway activation and gut microbiota modulation in rats

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 128, P. 106842 - 106842

Published: April 25, 2025

Language: Английский

Recent insights into Hericium erinaceus polysaccharides: Gastrointestinal, gut microbiota, microbial metabolites, overall health and structure-function correlation

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 311, P. 144013 - 144013

Published: May 6, 2025

Language: Английский