Recent Advances in the Development and Application of Cell-Loaded Collagen Scaffolds DOI Open Access
Qihao He, Tao Feng, Yijing Xie

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4009 - 4009

Published: April 24, 2025

Tissue engineering techniques aim to improve or replace biological tissues organs by utilizing the extracellular matrix facilitate repair of damaged organs. Collagen-based scaffolds offer numerous advantages, including excellent biocompatibility, low immunogenicity, biodegradability, hemostatic properties, and mechanical strength. Collagen can reconstruct microenvironment, promote cell adhesion, migration, proliferation, differentiation, play a critical role in cell-to-cell cell-to-matrix interactions. has been extensively utilized tissue organ reconstruction. This review examines properties collagen, its composition, structure, characteristics, regulating various cellular behaviors. Additionally, preparation cell-loaded collagen is discussed, along with comprehensive overview their applications tissues, skin, nerve, bone/cartilage, heart, liver, others. Emerging strategies future perspectives for clinical are also presented. provides synthesis mechanisms underlying use as advanced biomaterials, emphasizing potential expand collagen.

Language: Английский

Brewers’ Spent Grain-Derived Arabinoxylan as a Sustainable Filler for Enhanced PHBV Biocomposites DOI Open Access
Ilary Belardi, Fabrizio Sarasini, Jacopo Tirillò

et al.

Polymers, Journal Year: 2025, Volume and Issue: 17(1), P. 114 - 114

Published: Jan. 5, 2025

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a highly promising biodegradable and bio-based thermoplastic recognized for its environmental benefits potential versatility. However, industrial adoption has been limited due to inherent brittleness suboptimal processability. Despite these challenges, PHBV’s performance can be tailored wide range of applications through strategic modifications, particularly by blending it with other polymers or reinforcing natural fibers fillers. This study explores the brewers’ spent grain (BSG) as sustainable source development PHBV biocomposites. The biocomposites were synthesized incorporating arabinoxylan-bound benzoate, which derived from BSG, filler at concentrations 4% 10% w/w. resulting materials characterized using tensile testing, scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential calorimetry (DSC). findings demonstrate that incorporation functionalized arabinoxylan significantly enhances mechanical properties PHBV, preserves thermal stability, increases crystallinity (from 59.9% 67.6%), highlighting positive impact on both material processing characteristics.

Language: Английский

Citations

1
Multifunctional natural starch-based hydrogels: Critical characteristics, formation mechanisms, various applications, future perspectives DOI
Hong Wang, Liang Yang,

Yanning Yang

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 357, P. 123458 - 123458

Published: March 2, 2025

Language: Английский

Citations

1
Alginate-gelatin composite hydrogels for encapsulating Aloe vera extract; optimization, characterization, and release kinetics DOI Creative Commons

Shahrzad Ameli,

Moloud Nourani,

Nafiseh Bakhshi

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100717 - 100717

Published: Feb. 1, 2025

Language: Английский

Citations

0
Injectable organic-inorganic hybrid hydrogels for bone defect repair DOI Creative Commons
Huan Zhang,

Shuo Ding,

Xue Huai

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 18, 2025

Bone defects caused by trauma, tumor resection, and surgery present significant clinical challenges, often resulting in complications such as delayed union, nonunion, even long-term functional impairment. Current treatments, including autografts allografts, are limited donor site morbidity, immune rejection, pathogen transmission, highlighting the need for developing reliable synthetic alternatives. To address these we report a binary composite hydrogel combining gelatin methacryloyl (GelMA) κ-Carrageenan, reinforced with calcium phosphate cements (CPC). GelMA ensures rapid gelation biocompatibility, κ-carrageenan improves injectability, CPC enhances mechanical strength osteogenic activity, collectively creating robust versatile system. Furthermore, hydrogel's injectable, adaptive, self-healing characteristics enable it to conform irregular bone defect sites, providing support stimulation. It also releases bioactive components accelerate regeneration. With exceptional toughness resilience, this recovers its shape after deformation, positioning promising candidate repair applications.

Language: Английский

Citations

0
Eco-friendly Molecularly Imprinted Polymer-based Sensing Platforms Towards Pharmaceuticals: Recent Advances and Future Prospects DOI Creative Commons
Rüstem Keçili,

Ghazanfar Hussain,

Chaudhery Mustansar Hussain

et al.

Talanta Open, Journal Year: 2025, Volume and Issue: unknown, P. 100446 - 100446

Published: March 1, 2025

Language: Английский

Citations

0
A sustainable solution for environmental purification: A review of high-performance hydrogels based on chitosan DOI
Hong Wang, Liang Yang

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142834 - 142834

Published: April 1, 2025

Language: Английский

Citations

0
Eutectogels: Recent Advances and Emerging Biological Applications DOI
Yi Hu, Wenhui Yang,

Jiamian Zhan

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Eutectogels, a family of emerging materials, integrate the characteristics deep eutectic solvents (DES) and gels, presenting unique application potential in biomedical engineering. However, latest progress eutectogels their applications field remain to be summarized refined. This review first introduces composition properties generated by interaction between DES gel matrix. Subsequently, classifications advantages are comprehensively discussed according cross‐linked preparation methods, including physical, chemical, multiple cross‐linked. By analyzing eutectogels, such as mechanical performance, thermal properties, conductivity, injectability, structure‐function relationships, is overviewed. Then, eutectogel's prospects engineering elaborated detail, drug delivery improve stability precise control release, enhancing curative effects reducing side effects. Also, functional utilization tissue engineering, biosensing, bioadhesives, related domains explored. Finally, existing challenges prospective research directions delineated.

Language: Английский

Citations

0
Insights into the Versatile and Efficient Characteristics, Classifications, and Rational Design of Surface‐Grafted Smart Hydrogels DOI

Nehal,

Shikha Awasthi

Chemistry - An Asian Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Abstract Hydrogels have emerged as flexible biomaterials with enormous potential in biomedical applications due to their outstanding biocompatibility and ability hold a high water concentration. low toxicity are biodegradable. This review begins look at the various riveting characteristics classifications of hydrogel nanocomposites reinforced metallic ceramic components. A distinct focus is offered on thoroughly deliberating surface modification techniques special attention fabrication, patterning, fields. The describes value novel cross‐linking including physical, chemical, physical‐chemical dual adapting specific applications. also explains major bioapplication functionalized hydrogels. It emphasizes importance nanocomposite hydrogels multifunctional self‐assembled monolayers solving contemporary biological difficulties such infection control, medication delivery, tissue regeneration. need for interdisciplinary collaboration ongoing research efforts realize full nanomaterials Overall, this gives useful insights into current advances future possibilities grafted metals additives applications, highlighting multidisciplinary cooperation nano(bio)technology.

Language: Английский

Citations

0
Three-Dimensional-Bioprinted Embedded-Based Cerebral Organoids: An Alternative Approach for Mini-Brain In Vitro Modeling Beyond Conventional Generation Methods DOI Creative Commons
Rosalba Monica Ferraro, Paola Serena Ginestra, Miriam Seiti

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 284 - 284

Published: April 11, 2025

Cerebral organoids (cORGs) obtained from induced pluripotent stem cells (iPSCs) have become significant instruments for investigating human neurophysiology, with the possibility of simulating diseases and enhancing drug discovery. The current approaches require a strict process manual inclusion in animal-derived matrix Matrigel® are challenged by unpredictability, operators' skill expertise, elevated costs, restricted scalability, impeding their extensive applicability translational potential. In this study, we present novel method to generate brain that address these limitations. Our approach does not manual, operator-dependent embedding. Instead, it employs chemically defined hydrogel which is diluted solution enriched sodium alginate (SA) carboxymethylcellulose (CMC) used as bioink print neural embryoid bodies (nEBs). Immunohistochemical, immunofluorescence, gene expression analyses confirmed SA-CMC-Matrigel® can sustain generation iPSC-derived cortical cORGs conventional Matrigel®-based does. By day 40 differentiation, hydrogel-based 3D-bioprinted showed heterogeneous consistent masses, cytoarchitecture resembling an early-stage developmental fetal composed progenitor PAX6+/Ki67+ organized into tubular structures, densely packed cell somas neurites SYP+, suggestive tissue-like neuronal layer formation.

Language: Английский

Citations

0
Recent Advances in the Development and Application of Cell-Loaded Collagen Scaffolds DOI Open Access
Qihao He, Tao Feng, Yijing Xie

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4009 - 4009

Published: April 24, 2025

Tissue engineering techniques aim to improve or replace biological tissues organs by utilizing the extracellular matrix facilitate repair of damaged organs. Collagen-based scaffolds offer numerous advantages, including excellent biocompatibility, low immunogenicity, biodegradability, hemostatic properties, and mechanical strength. Collagen can reconstruct microenvironment, promote cell adhesion, migration, proliferation, differentiation, play a critical role in cell-to-cell cell-to-matrix interactions. has been extensively utilized tissue organ reconstruction. This review examines properties collagen, its composition, structure, characteristics, regulating various cellular behaviors. Additionally, preparation cell-loaded collagen is discussed, along with comprehensive overview their applications tissues, skin, nerve, bone/cartilage, heart, liver, others. Emerging strategies future perspectives for clinical are also presented. provides synthesis mechanisms underlying use as advanced biomaterials, emphasizing potential expand collagen.

Language: Английский

Citations

0