Alginate ameliorates hyperuricemia in mice by restoring hyperuricemia-induced renal and intestinal dysfunctions DOI Creative Commons

Rongshuang Han,

Yukun Li, Yingjie Guo

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143422 - 143422

Published: April 1, 2025

Alginate, a bioactive polysaccharide fermentable by gut microbiota, has been shown to effectively reduce serum uric acid levels. However, its mechanisms and the role of microbiota remain unclear. In this study, we explored effects alginate with two different molecular weights on hyperuricemia mice. Both alginates exhibited potent hypouricemic through ABCG2 transporter upregulation, ameliorating hyperuricemia-induced renal intestinal dysfunctions, low-molecular-weight demonstrating enhanced bioavailability microbial biodegradation superior therapeutic efficacy in management. Additionally, found that alleviates dysbiosis induced enriching potentially beneficial bacteria. These include Limosilactobacillus Lactobacillus, which show significant negative correlation bacteria might regulate precursors during purine metabolism, thereby reducing accumulation. summary, study reveals protective damage mice highlights crucial microbiota. It provides valuable insights into mediate alginate.

Language: Английский

Alginate ameliorates hyperuricemia in mice by restoring hyperuricemia-induced renal and intestinal dysfunctions DOI Creative Commons

Rongshuang Han,

Yukun Li, Yingjie Guo

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143422 - 143422

Published: April 1, 2025

Alginate, a bioactive polysaccharide fermentable by gut microbiota, has been shown to effectively reduce serum uric acid levels. However, its mechanisms and the role of microbiota remain unclear. In this study, we explored effects alginate with two different molecular weights on hyperuricemia mice. Both alginates exhibited potent hypouricemic through ABCG2 transporter upregulation, ameliorating hyperuricemia-induced renal intestinal dysfunctions, low-molecular-weight demonstrating enhanced bioavailability microbial biodegradation superior therapeutic efficacy in management. Additionally, found that alleviates dysbiosis induced enriching potentially beneficial bacteria. These include Limosilactobacillus Lactobacillus, which show significant negative correlation bacteria might regulate precursors during purine metabolism, thereby reducing accumulation. summary, study reveals protective damage mice highlights crucial microbiota. It provides valuable insights into mediate alginate.

Language: Английский

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