Polyvinyl Alcohol-Based Membranes: A Review of Research Progress on Design and Predictive Modeling of Properties for Targeted Application

Polymers, Journal Year: 2025, Volume and Issue: 17(8), P. 1016 - 1016

Published: April 9, 2025

This review provides a comprehensive evaluation of the current state polyvinyl alcohol (PVA)-based membranes, emphasizing their significance in membrane technology for various applications. The analysis encompasses both experimental and theoretical research articles, with focus on recent decades, aiming to elucidate potential limitations different fabrication approaches, structure–property relationships, applicability real world. begins by examining advanced polymeric materials strategies employed design processing membranes tailored properties. Fundamental principles processes are introduced, general modeling approaches describing fluid transport through membranes. A key aspect discussion is distinction between performance process performance. Additionally, an in-depth PVA applications presented, particularly environmental fields (e.g., fuel cell, water treatment, air purification, food packaging) biomedical domains drug delivery systems, wound healing, tissue engineering regenerative medicine, hemodialysis artificial organs, ophthalmic periodontal treatment). Special attention given relationship membranes’ characteristics, such as material composition, structure, parameters, overall performance, terms permeability, selectivity, stability. Despite promising properties, enhanced innovative methods that expand applicability, challenges remain optimizing long-term stability, improving fouling resistance, increasing scalability. Therefore, further needed develop novel modifications composite structures overcome these enhance practical implementation PVA-based By offering systematic overview, this aims advance understanding fabrication, functionality, providing valuable insights continued development optimization technology.

Language: Английский

Comparative analysis of PLGA ocuserts of brimonidine tartrate prepared with different methods

European Pharmaceutical Journal, Journal Year: 2025, Volume and Issue: unknown

Published: May 17, 2025

Abstract The eye is a highly sensitive organ with multiple physiological barriers that limit drug bioavailability and reduce patient compliance. Research studies are still going on to discover novel delivery system for ocular delivery. current research aims develop compare the PLGA ocuserts of brimonidine tartrate (BT) by different methods. These BT-loaded offer promising alternative commercially available BT drops. Ocuserts could significantly minimize challenges encountered drops like lacrimation, blinking-induced washout, dosing frequency, penetration, stability, controlled release issues. were prepared using two methods: solvent casting method (SCM) glass substrate (GSM). Both SCM GSM formulations exhibited smooth texture, pH levels within range 6.88±0.24 6.90±0.28, uniform thickness (SCM: 0.47±0.10 mm; GSM: 0.29±0.03 mm), minimal weight variation 7.83±0.38 mg; 6.55±0.76 mg), sterility, appropriate swelling indices 6.69±0.33%; 5.40±0.27%). evaluation results revealed positive attributes ophthalmic use. Noteworthy distinctions emerged in folding endurance, demonstrating higher endurance (87.17±4.34 folds) than (71.33±4.82 folds). Moreover, superior entrapment efficiency (88.26±3.33 %) (74.91±4.39 %). Stability confirmed good stability over 6-month period, while vitro (italics) study indicated better properties GSM. Findings demonstrate as an effective preparation polymeric films various pharmaceutical industries, including transdermal patches, scaffolds tissue engineering, flexible wound healing films, biodegradable systems, packaging well.

Language: Английский