Micron-Sized Fe3O4/PCL Biocomposite Scaffolds to Attract Magnetic Nanoparticles for Targeted Drug Delivery DOI Creative Commons
Jianhua Ge,

Riley Drees,

Aoran Wang

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(4), P. 371 - 371

Published: April 1, 2025

Adjuvant chemotherapy is a critical regime in cancer treatment. The magnetic targeted drug delivery system (MTDDS) can selectively aggregate agents at the target areas, which has attracted great attention due to its safety, high efficiency, and minimal side effects on human body. It would be ideal establish tissue engineering scaffold that not only reconstruct defect from surgical tumor removal, but also serve as station attract MTDDS local site enhance delivery. current study constructed polycaprolactone scaffolds with various micrometer-sized magnets. degradation properties of were assessed simulated body fluid (SBF), primary mouse bone marrow stromal cells used evaluate biocompatibility osteoblast differentiations. further examined by implantation an air pouch model back BALB/c mice. vitro data suggested up 40% micron-sized magnetite formulate porous (PCL) comparable PCL-alone scaffold. A revealed intro-peritoneal injected fluorescence-magnetic particles collectedly enriched tissues containing 20% magnetic/PCL scaffolds. Histological assessment real-time PCR results pouches confirmed benign implanted

Language: Английский

Curcumin-crosslinked single-chain polymer nanoparticles as potential polymer-drug conjugates DOI

Hatice Kübra Batu,

Dilek Öztürk Civelek, Binnur Aydogan Temel

et al.

International Journal of Polymeric Materials, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: March 27, 2025

Language: Английский

Citations

0
Micron-Sized Fe3O4/PCL Biocomposite Scaffolds to Attract Magnetic Nanoparticles for Targeted Drug Delivery DOI Creative Commons
Jianhua Ge,

Riley Drees,

Aoran Wang

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(4), P. 371 - 371

Published: April 1, 2025

Adjuvant chemotherapy is a critical regime in cancer treatment. The magnetic targeted drug delivery system (MTDDS) can selectively aggregate agents at the target areas, which has attracted great attention due to its safety, high efficiency, and minimal side effects on human body. It would be ideal establish tissue engineering scaffold that not only reconstruct defect from surgical tumor removal, but also serve as station attract MTDDS local site enhance delivery. current study constructed polycaprolactone scaffolds with various micrometer-sized magnets. degradation properties of were assessed simulated body fluid (SBF), primary mouse bone marrow stromal cells used evaluate biocompatibility osteoblast differentiations. further examined by implantation an air pouch model back BALB/c mice. vitro data suggested up 40% micron-sized magnetite formulate porous (PCL) comparable PCL-alone scaffold. A revealed intro-peritoneal injected fluorescence-magnetic particles collectedly enriched tissues containing 20% magnetic/PCL scaffolds. Histological assessment real-time PCR results pouches confirmed benign implanted

Language: Английский

Citations

0