Curcumin Microcapsule Formulations for Prolong Persistence in the Photodynamic Inactivation of Aedes aegypti Larvae DOI Creative Commons
Matheus Garbuio, Larissa Marila de Souza, Lucas D. Dias

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 496 - 496

Published: April 9, 2025

Background: Viral diseases including dengue, zika, chikungunya, and yellow fever remain a significant public health challenge, primarily due to the increasing resistance of these vectors, Aedes aegypti mosquito, conventional control methods. Objectives: Herein, microencapsulated curcumin formulation was developed characterized using spray-drying technology, with D-mannitol starch as encapsulating agents. After microencapsulation, photolarvicidal tablet formulations (Formulated Curcumin Tablets—FCT) were prepared, varying proportions pectin: FCT1 (60% starch), FCT2 (35% pectin 25% FCT3 (42.5% 17.5% while maintaining 10% 30% in all formulations. The main goal enhance stability efficacy agent. Methods: by UV-Vis spectroscopy, confocal microscopy, thermal analysis (TG DSC), scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), photodegradation assays under fluorescent light. Results: photodynamic inactivation (PDI) Ae. larvae evaluated white, light exposure, exhibited significantly enhanced larvicidal activity compared free curcumin, 57-fold reduction LC50 (LC50-24h = 0.27 mg/L). Additionally, most effective formulation, FCT2, maintained its residual for 27 days, reinforcing that combined PDI, can extend vector control. Release studies different pH conditions confirmed controlled release mechanism, favoring environmental stability. Conclusions: results indicate has great potential sustainable photoinsecticidal agent, offering stability, efficacy, promising alternative managing larval populations.

Language: Английский

Curcumin Microcapsule Formulations for Prolong Persistence in the Photodynamic Inactivation of Aedes aegypti Larvae DOI Creative Commons
Matheus Garbuio, Larissa Marila de Souza, Lucas D. Dias

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 496 - 496

Published: April 9, 2025

Background: Viral diseases including dengue, zika, chikungunya, and yellow fever remain a significant public health challenge, primarily due to the increasing resistance of these vectors, Aedes aegypti mosquito, conventional control methods. Objectives: Herein, microencapsulated curcumin formulation was developed characterized using spray-drying technology, with D-mannitol starch as encapsulating agents. After microencapsulation, photolarvicidal tablet formulations (Formulated Curcumin Tablets—FCT) were prepared, varying proportions pectin: FCT1 (60% starch), FCT2 (35% pectin 25% FCT3 (42.5% 17.5% while maintaining 10% 30% in all formulations. The main goal enhance stability efficacy agent. Methods: by UV-Vis spectroscopy, confocal microscopy, thermal analysis (TG DSC), scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), photodegradation assays under fluorescent light. Results: photodynamic inactivation (PDI) Ae. larvae evaluated white, light exposure, exhibited significantly enhanced larvicidal activity compared free curcumin, 57-fold reduction LC50 (LC50-24h = 0.27 mg/L). Additionally, most effective formulation, FCT2, maintained its residual for 27 days, reinforcing that combined PDI, can extend vector control. Release studies different pH conditions confirmed controlled release mechanism, favoring environmental stability. Conclusions: results indicate has great potential sustainable photoinsecticidal agent, offering stability, efficacy, promising alternative managing larval populations.

Language: Английский

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