Tri-network PVA/chitosan/gelatin hydrogel modified by tannic acid with self-healing, adhesive and anti-inflammatory properties to accelerate wound healing

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142280 - 142280

Published: March 1, 2025

Language: Английский

Robust Injectable Hydrogels for Hemophilic Arthropathy via Anti‐Inflammation, Iron Removal and Cartilage Protection

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract Hemophilic arthropathy (HA), a form of arthritis associated with joint bleeding, presents extra challenges in treatment due to intermittent bleeding‐induced iron‐overloading, oxidative stress, and inflammation. Conventional therapeutic approaches have predominantly concentrated on achieving hemostasis reducing inflammation, yet they fallen short effectively managing iron overload safeguarding cartilage, resulting less‐than‐ideal outcomes. To address these issues, series injectable hydrogels is facilely fabricated via one‐step assembly polyphenols, chelators, lipoic acid. In vitro investigations demonstrate that the not only good performances antioxidation anti‐inflammation, but also exhibit promising prospects removal, adhesion resistance, wear resistance. Moreover, vivo studies are further carried out indicate diminished inflammatory response, ameliorative iron‐overload‐related lesion indicators, cartilage preservation. This class robust multifunctional composed clinically available drugs along commonly used commercial ingredients would offer new opportunities toward efficient HA.

Language: Английский

Natural polysaccharide-based nanodrug delivery systems for targeted treatment of rheumatoid arthritis: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143408 - 143408

Published: April 1, 2025

Language: Английский