Metal ion crosslinked polysaccharide hydrogels: A review on their potential for therapeutic delivery and tissue engineering DOI

Riya Hazra,

Md Sahil Shanawaz Alam,

Ashim Malakar

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143467 - 143467

Published: April 23, 2025

Language: Английский

Cascade Nanozyme-Loaded Sprayable Hydrogels for Fibroblast Rejuvenation and Diabetic Wound Regeneration DOI
Xinyi Zhang, Yuan Yang, Jianyu Su

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Multifunctional composite wound dressings hold significant promise for diabetic healing. However, the detrimental role of advanced glycation end-products (AGEs)-reactive oxygen species (ROS) cycle in impeding repair remains underexplored. To disrupt this pathological cycle, zeolitic imidazolate framework-8 (ZIF-8) encapsulated cerium dioxide (CeO2) and adsorbed glucose oxidase (GOx) nanozyme particles ((ZIF-8@CeO2)@GOx, zcg) were loaded into a methacrylic anhydride-modified gelatin (GelMA) hydrogel to form sprayable dressing, zcg/GelMA (zcgG). Physicochemical characterization revealed that GOx catalyzes oxidation, triggering ZIF-8 acid-mediated decomposition release zinc ions CeO2 nanoparticles, thereby enabling cascade depletion, antioxidant, antiglycation functions. In vitro antimicrobial cytotoxicity experiments optimized zcg concentration GelMA. Under oxidative hyperglycemic culture conditions, we validated mechanism blocking AGEs-ROS restoring fibroblast mitochondrial membrane potential, subsequently suppressing cellular senescence. bacterial-infected rat skin model, zcgG group demonstrated substantially reduced inflammatory levels, 68% decrease AGEs, 1.9-fold increase collagen deposition compared blank controls. Within 2 weeks, achieved complete closure, while control retained 28% initial area. This work provides preliminary evidence feasibility using nanozymes break promote

Language: Английский

Citations

0
A gelatin microneedles featuring antibacterial and reactive oxygen species scavenging properties for treating Vibrio vulnificus-infected wounds DOI

Yuling Shu,

Yi Qi, Yan Zou

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142640 - 142640

Published: March 1, 2025

Language: Английский

Citations

0
Mussel-inspired bifunctional chimeric peptides macromolecules functionalize 3D-printed porous scaffolds for enhanced antimicrobial and osseointegration properties in bone defect repair DOI

Ziyang Bai,

Yifan Zhao,

Wenjun Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142668 - 142668

Published: March 1, 2025

Language: Английский

Citations

0
Injectable dual-cross-linked microalgae-silk gel ameliorates diabetic wound healing by promoting oxygenation and ROS clearance and lessening inflammation DOI

Liuting Chen,

Yao Li, Na Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 309, P. 142897 - 142897

Published: April 8, 2025

Language: Английский

Citations

0
Metal ion crosslinked polysaccharide hydrogels: A review on their potential for therapeutic delivery and tissue engineering DOI

Riya Hazra,

Md Sahil Shanawaz Alam,

Ashim Malakar

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143467 - 143467

Published: April 23, 2025

Language: Английский

Citations

0