Hydrogel Based on Bletilla Striata Polysaccharide for Sustained Sodium Danshensu Release for Wound Healing DOI
Xinyu Gao, Xinjiani Chen,

Sun Ho Song

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Bletilla striata polysaccharide (BSP) is effective at healing wounds and has important application value in the research development of biomedical materials. In this study, BSP, chitosan, sodium β-glycerophosphate were used to generate a complex hydrogel with very small pore size 10-30 μm without use cross-linking agents. By improving density, mechanical property defects caused by excessive BSP dissolution overcome affecting its physiological activity. Moreover, molecule Danshen (SDSS) was loaded into three-dimensional network form drug carrier system. SDSS could be released long term, total amount after 53 h 96.26 ± 2.57%. The had good water absorption (169.47 4.54%) bonding properties. vitro studies confirmed that it antibacterial performance biocompatibility ability promote cell proliferation (>200%) migration. Molecular experiments promotes collagen expression. vivo using mouse wound model an excellent healing, particularly during first 7 days wound. rate group higher than blank 27.61% (p < 0.05), effect tissue staining.

Language: Английский

Development and characterization of biodegradable antibacterial hydrogels of xanthan gum for controlled ciprofloxacin release DOI

Siru Huang,

Susu An,

Perumal Ramesh Kannan

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142637 - 142637

Published: March 1, 2025

Language: Английский

Citations

0
Hydrogel Based on Bletilla Striata Polysaccharide for Sustained Sodium Danshensu Release for Wound Healing DOI
Xinyu Gao, Xinjiani Chen,

Sun Ho Song

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Bletilla striata polysaccharide (BSP) is effective at healing wounds and has important application value in the research development of biomedical materials. In this study, BSP, chitosan, sodium β-glycerophosphate were used to generate a complex hydrogel with very small pore size 10-30 μm without use cross-linking agents. By improving density, mechanical property defects caused by excessive BSP dissolution overcome affecting its physiological activity. Moreover, molecule Danshen (SDSS) was loaded into three-dimensional network form drug carrier system. SDSS could be released long term, total amount after 53 h 96.26 ± 2.57%. The had good water absorption (169.47 4.54%) bonding properties. vitro studies confirmed that it antibacterial performance biocompatibility ability promote cell proliferation (>200%) migration. Molecular experiments promotes collagen expression. vivo using mouse wound model an excellent healing, particularly during first 7 days wound. rate group higher than blank 27.61% (p < 0.05), effect tissue staining.

Language: Английский

Citations

0