Development of Poly(ether sulfone)/Poly(vinyl alcohol)/Magnesium-Doped Carbon Quantum Dot Scaffolds for Bone Tissue Engineering DOI
Mohamadreza Shakiba, Hamidreza Abdouss, Salar Mohammadi Shabestari

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Bone tissue engineering plays a critical role in overcoming the limitations of traditional bone grafts and implants by enhancing integration regeneration. In this study, we developed novel membrane scaffold comprising poly(ether sulfone) (PES), poly(vinyl alcohol) (PVA), magnesium-doped carbon quantum dots (CQDs.Mg) for potential applications. Four distinct formulations (PE-CM0, PE-CM2, PE-CM3, PE-CM4) were using film applicator machine. The morphology porosity scaffolds, characterized via scanning electron microscopy (SEM), revealed increased with higher CQDs.Mg content. Fourier transform infrared spectroscopy (FTIR) confirmed successful functional groups from each component. Water contact angle (WCA) measurements indicated improved hydrophilicity addition CQDs.Mg, which is beneficial cell attachment proliferation. Mechanical testing demonstrated that scaffolds maintained adequate tensile strength flexibility, PE-CM3 PE-CM4 exhibiting superior properties. Swelling assays enhanced water absorption content, while 14-day degradation studies showed excellent structural stability. Biocompatibility was also assessed L929 NIH3T3 lines, cytotoxicity demonstrating nearly 100% viability across all samples. These findings suggest PES/PVA/CQDs.Mg exhibit promising combination mechanical robustness, hydrophilicity, biocompatibility, making them strong candidates

Language: Английский

Development of Poly(ether sulfone)/Poly(vinyl alcohol)/Magnesium-Doped Carbon Quantum Dot Scaffolds for Bone Tissue Engineering DOI
Mohamadreza Shakiba, Hamidreza Abdouss, Salar Mohammadi Shabestari

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Bone tissue engineering plays a critical role in overcoming the limitations of traditional bone grafts and implants by enhancing integration regeneration. In this study, we developed novel membrane scaffold comprising poly(ether sulfone) (PES), poly(vinyl alcohol) (PVA), magnesium-doped carbon quantum dots (CQDs.Mg) for potential applications. Four distinct formulations (PE-CM0, PE-CM2, PE-CM3, PE-CM4) were using film applicator machine. The morphology porosity scaffolds, characterized via scanning electron microscopy (SEM), revealed increased with higher CQDs.Mg content. Fourier transform infrared spectroscopy (FTIR) confirmed successful functional groups from each component. Water contact angle (WCA) measurements indicated improved hydrophilicity addition CQDs.Mg, which is beneficial cell attachment proliferation. Mechanical testing demonstrated that scaffolds maintained adequate tensile strength flexibility, PE-CM3 PE-CM4 exhibiting superior properties. Swelling assays enhanced water absorption content, while 14-day degradation studies showed excellent structural stability. Biocompatibility was also assessed L929 NIH3T3 lines, cytotoxicity demonstrating nearly 100% viability across all samples. These findings suggest PES/PVA/CQDs.Mg exhibit promising combination mechanical robustness, hydrophilicity, biocompatibility, making them strong candidates

Language: Английский

Citations

0