Associations of complete blood cell count-derived inflammatory biomarkers with asthma and mortality in adults: a population-based study

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: July 28, 2023

This study aims to assess the associations of complete blood cell count (CBC)-derived inflammatory biomarkers with prevalence asthma and mortality.Data was collected from 1999-2018 National Health Nutrition Examination Survey (NHANES). Mortality identified using Death Index until December 31, 2019. The analyzed relationship between CBC-derived biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR), systemic response index (SIRI), immune-inflammation (SII), multiple logistic regressions. To significance in predicting all-cause respiratory disease mortality patients, Cox proportional regressions random survival forest (RSF) analysis were utilized.A total 48,305 participants included, a mean age 47.27 ± 0.18 years 49.44% male. Among them, 6,403 had asthma, 13.28%. deaths at median follow-up 8.2 (4.5, 12.8) 929 137 respectively. After adjusting for confounders, found be positively associated NLR, PLR, MLR, SIRI SII. Compared lowest quartile, highest quartile NLR (HR=1.765 [1.378-2.262]), MLR (HR=1.717 [1.316-2.241]), (HR=1.796 [1.353-2.383]) SII (HR=1.432 [1.141-1.797]) an increased risk mortality. These more pronounced patients. RSF showed that predictive value adults asthma. sensitivity demonstrated stability our results.The findings suggest are higher

Language: Английский

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The associations of two novel inflammation indexes, systemic immune-inflammation index (SII) and system inflammation response index (SIRI), with periodontitis: evidence from NHANES 2009–2014

Clinical Oral Investigations, Journal Year: 2024, Volume and Issue: 28(2)

Published: Feb. 1, 2024

Language: Английский

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Klotho exerts protection in chronic kidney disease associated with regulating inflammatory response and lipid metabolism

Cell & Bioscience, Journal Year: 2024, Volume and Issue: 14(1)

Published: April 7, 2024

The anti-aging protein Klotho plays a protective role in kidney disease, but its potential as biomarker for chronic disease (CKD) is controversial. Additionally, the main pathways through which exerts effects on CKD remain unclear. Therefore, we used bioinformatics and clinical data analysis to determine CKD.

Language: Английский

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The association between triglyceride-glucose index and its combination with systemic inflammation indicators and all-cause and cardiovascular mortality in the general US population: NHANES 1999–2018

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 10, 2024

Language: Английский

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The Systemic Immune Inflammatory Response Index Can Predict the Clinical Prognosis of Patients with Initially Diagnosed Coronary Artery Disease

Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 5069 - 5082

Published: Nov. 1, 2023

Recently, the systemic immune inflammatory response index (SIIRI), a novel and expanded marker, has been an independent predictor of lesion severity in patients with acute coronary syndrome (ACS). However, its predictive role initially diagnosed artery disease (CAD) remains to be explored.We evaluated 959 CAD undergoing initial intervention. Each patient had laboratory measurements, including blood cell counts, taken after admission before interventional treatment. The primary endpoint was major cardiovascular events (MACEs), defined as death, nonfatal myocardial infarction(MI), stroke. secondary endpoints included MACEs readmission for congestive heart failure(HF).During mean follow-up period 33.3±9.9 months, 229 (23.9%) were recorded. ROC curve analysis displayed that best cut-off value SIIRI predicting 247.17*1018/L2. Kaplan-Meier survival showed rate low group higher than high (P<0.001). Compared group, significantly risk (187 cases (39.53%) vs.42 (8.64%), P<0.001). Univariate multivariate Cox regression analyses levels independently associated occurrence percutaneous intervention (PCI) (adjusted hazard ratio [HR]: 3.808, 95% confidence interval [CI%]: 2.643-5.486, Adding conventional factor models improved MACEs.Elevated is adverse prognosis CAD. can simple practical identify high-risk PCI.

Language: Английский

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Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in general population: evidence from NHANES 1999–2010

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 25, 2024

Chronic inflammation is a recognized independent risk factor for cardiovascular disease (CVD), highlighting the need reliable inflammatory indicator to predict CVDs. As an which has been proved have predictive value prognosis of CVDs, neutrophil percentage-to-albumin ratio (NPAR) obtained increasing attention, but further research needed confirm relationship with mortality in general population. This prospective cohort study included 21,317 individuals who participated National Health and Nutrition Examination Survey (NHANES) from 1999 2010, where baseline characteristics NPAR level were extracted. Data CVD all-cause acquired by linking database Death Index through December 31, 2019. We employed restricted cubic spline analyses examine nonlinear association. Weighted Kaplan-Meier curves log-rank tests conducted access cumulative survival differences across different results. Multivariable Cox proportional hazards regression models used compute hazard ratios 95% CIs. Receiver Operating Characteristic (ROC) compare systemic immune index (SII) neutrophils percent. In this study, during 270,014 person-years follow-up, 4,074 deaths 1,116 CVD-cause documented. levels exhibited significant associations both (P = 0.018 nonlinearity) < 0.001 nonlinearity). Participants highest tertile had significantly increased (HR: 1.46, CI: 1.33-1.61) 1.54, 1.32-1.80) compared those lowest fully adjusted model, while no association was detected middle tertile. Further ROC analysis confirmed that higher than percent segment SII. Elevated associated The high NPAR, combined easy-to-calculate property, suggests its potential as novel worthy investigation.

Language: Английский

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Assessment of the Severity of Intermediate Coronary Artery Stenosis Using the Systemic Inflammatory Response Index

Diagnostics, Journal Year: 2025, Volume and Issue: 15(2), P. 162 - 162

Published: Jan. 13, 2025

Background: Fractional Flow Reserve (FFR) is a method that enables the hemodynamic assessment of coronary artery stenosis. The Systemic Inflammatory Response Index (SIRI) new marker calculated by multiplying neutrophil-to-lymphocyte ratio (NLR) with monocyte count. It indicative presence and severity disease. This study evaluates relationship between functional significance FFR measurements SIRI in intermediate Methods: A total 294 patients 50–70% stenosis their arteries based on quantitative measurement following angiography who underwent were included before procedure. Total differential leukocyte counts routine biochemical tests performed. Results: 37% found to have positive FFR, while 63% had negative FFR. Significant differences observed neutrophil count, Inflammation (SIRI), cholesterol, amount adenosine used groups (p < 0.05). value 1.16 was 77% sensitive 55% specific for positivity. Multivariate logistic regression analysis identified as an independent predictor Conclusions: Our has demonstrated high values may serve biomarker predicting

Language: Английский

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Association of neutrophil-to-lymphocyte ratio and monocyte-tolymphocyte ratio with all-cause mortality in patients with ischemia and non-obstructive coronary arteries

Revista română de medicină de laborator, Journal Year: 2025, Volume and Issue: 33(1), P. 21 - 28

Published: Jan. 1, 2025

Abstract Background Ischemia with non-obstructive coronary arteries (INOCA) is a frequent syndrome important impact on morbimortality. Systemic inflammation, key pathophysiological mechanism in its development, reflected diverse bio-markers, such as the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte (MLR) and platelet-to-lymphocyte (PLR). In this retrospective observational study, we aimed to assess value of NLR, MLR PLR predictors all-cause long-term mortality INOCA patients. Methods Acute/ chronic consecutive patients hospitalized from January 2014 December 2019 were included, after excluding pulmonary hypertension, acute non-cardiac pathology, in-hospital mortality. The primary endpoint was Results Our cohort included 238 (62.2% female, mean age 64.1±9.5 years). Of all patients, 14.3% reached during 5.8±1.1 years follow-up. Age (OR=1.10, p <0.001), diabetes mellitus (OR 2.54, =0.01), heart failure (OR=3.73, =0.003), atrial fibrillation (OR=3.52, =0.001), severe valve disease (OR=3.99, NT-proBNP (OR=3.28, 3rd tertile NLR (OR=4.33, <0.001) (OR=4.34, predictors, while not. multivariable analysis baseline prediction model (HR=1.12, (HR=3.78, <0.001). Adding NLR>2.99 (HR=4.58, MLR>0.36 (HR=4.74, or both increased power predictive chi-square 33.00 51.08 ( Conclusions INOCA, independently correlated most accurate NLR>2.99, MLR>0.36, diagnosis failure.

Language: Английский

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Inflammatory and Fibrosis Parameters Predicting CPET Performance in Males with Recent Elective PCI for Chronic Coronary Syndrome

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 510 - 510

Published: March 21, 2025

Functional capacity (FC), ideally determined by a cardiopulmonary exercise test (CPET), is valuable prognostic marker in chronic coronary syndrome (CCS). As CPET has limited availability, biomarkers of inflammation and/or fibrosis could help predict diminished FC. Our objective was to assess the value galectin-3 (gal-3) and that three inflammatory markers easily obtained from complete blood count (NLR (neutrophil-to-lymphocyte ratio), PLR (platelet-to-lymphocyte ratio) MLR (monocyte-to-lymphocyte predicting FC males with recent elective percutaneous intervention (PCI) for CCS. prospective study enrolled 90 who had undergone PCI previous 3 months (mean age 60.39 ± 10.39 years) referred cardiovascular rehabilitation (CR) clinic between February 2023 December 2024. All subjects received clinical examination, stress test, transthoracic echocardiography bloodwork. Based on percentage predicted oxygen uptake (%VO2max), patients were classified two subgroups—impaired (≤70%, n = 50) preserved (>70%, 40). NLR, gal-3 elevated poor significant predictors multivariate analysis. PLR, NLR guide referrals CR high-risk PCI.

Language: Английский

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Association between monocyte-to-lymphocyte ratio and cardiovascular diseases: insights from NHANES data

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: March 24, 2025

Abstract Background This study intends to examine any possible correlation between monocyte-to-lymphocyte ratio (MLR) and cardiovascular diseases (CVD). Methods Data from the 1999–2020 National Health Nutrition Examination Survey (NHANES) in USA were analyzed. Heart attacks, angina pectoris, congestive heart failure (CHF), coronary disease (CHD), stroke all covered by CVD. The independent relationships these events MLR levels, as well other inflammatory indices (system inflammation response index (SIRI), aggregate of systemic (AISI), C-reactive protein-to-albumin (CAR)), investigated. Furthermore, interaction tests subgroup analysis performed. Diagnostic capacities also predicted compared using receiver operating characteristic (ROC) curves. Results Males made up 49.63% 46,289 people who recruited this study. prevalence CVD its follows: CHF at 2.99%, CHD 3.72%, pectoris 2.57%, attacks 3.94%, 3.48%, with itself 7.98%. positively correlated. Specifically, smooth curve fittings found a non-linear relationship Moreover, higher levels linked increased rates CHF, CHD, strokes. SIRI wa s have positive outperformed (SIRI, AISI, CAR) terms discriminative capacity accuracy predicting CVD, attack, stroke, according ROC analysis. Conclusions Compared indicators CAR), appears be better for stroke. American adults elevated should aware harm caused Causal inference is, however, limited cross-sectional design dependence on self-reported data. Further longitudinal studies are needed validate findings.

Language: Английский

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