Gender differences in the relationship between cardiometabolic index and all-cause and specific mortality in the United States adults: a national study

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 17, 2025

Background The cardiometabolic index (CMI) is a new comprehensive measure that reflects visceral obesity and metabolic function. This study aimed to examine associations between CMI adult mortality from all causes specific causes, as well gender differences, using the National Health Nutrition Examination Survey (NHANES) database. Methods We included 37,539 participants with complete data 1999-2018 NHANES categorized according constructed three models investigate relationship outcome variables. These were analyzed Kaplan-Meier curve analysis, COX proportional risk models, restricted cubic spline (RCS). Results Baseline characteristics showed among both male female participants, those who died exhibited higher levels of compared survived. curves an increasing trend in all-cause follow-up time. When was quartiles (Q1-Q4), probability survival lower Q4 group Q1. found no differences rates. In regression analyses, all-cause, cardiovascular, diabetes significantly whole population whereas significant identified participants. RCS nonlinear positive correlation for females linear cardiovascular mortality. As males, positively nonlinearly associated Besides, there statistically males Conclusion There mortality, population. findings indicated elevated at disease, diabetes. At same time, males.

Language: Английский

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Association Between Two Novel Visceral Obesity Indicators and Heart Failure Among US Adults: A Cross-Sectional Study

Metabolic Syndrome and Related Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Background: This study aimed to explore the association of cardiometabolic index (CMI), CMI-age, visceral adiposity (VAI), and VAI-age with heart failure (HF) compare those indicators for early identification HF.

Language: Английский

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National Cohort Study on Cardiometabolic Index and Incident Stroke in Middle-Aged and Older Adults in China

Journal of Stroke and Cerebrovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 108270 - 108270

Published: March 1, 2025

The Cardiometabolic Index (CMI), a novel marker integrating central obesity and lipid metabolism, serves as comprehensive indicator of metabolic health. While CMI has been linked to disorders like diabetes cardiovascular diseases, its role in predicting stroke risk remains unclear. This study examines the association between Chinese adults aged 45 older, highlighting potential predictive tool for public Data from China Health Retirement Longitudinal Study (CHARLS) were analyzed. Participants divided into quartiles. Stroke incidence was primary endpoint. Cox proportional hazards models evaluated CMI-stroke association. Kaplan-Meier curves compared across quartiles, while restricted cubic splines (RCS) assessed non-linear trends. Subgroup analyses verified robustness. Among 7,821 participants (47% male), 418 strokes (5.3%) occurred over mean follow-up 7 years. Higher significantly associated with increased [HR, 1.153 (95% CI: 1.048-1.269), P = 0.004]. RCS revealed rise increasing (P nonlinearity 0.005). No significant interactions observed subgroups (all > 0.05). Elevated correlates higher middle-aged older adults. Incorporating routine assessments could improve early prevention strategies, addressing burden cerebrovascular disease aging populations.

Language: Английский

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Association of cardiometabolic index and new-onset stroke in middle-aged and elderly Chinese: a national prospective cohort study

BMC Neurology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 13, 2025

The Cardiometabolic Index (CMI), a novel metabolic marker, has been associated with various diseases in previous studies. However, its relationship stroke risk remains underexplored. This study investigates the potential correlation between CMI and among Chinese adults aged 45 older. In China Health Retirement Longitudinal Study (CHARLS), participants were categorized into four groups based on quartiles. primary outcome was incidence of new strokes during follow-up period. A Cox proportional hazards model used to analyze elderly. Kaplan–Meier survival analysis compared rates across levels, restricted cubic splines (RCS) assessed non-linear relationships stroke. Subgroup analyses verified robustness these findings. included 6620 patients (45% male), 417 cases reported over an average seven years. Multivariate indicated significant association increased higher [HR, 1.132 (1.021–1.273), P = 0.003]. RCS revealed nonlinear increase rising levels (P for nonlinearity 0.006). No interactions detected selected subgroups (all values interaction > 0.05). significantly correlates elderly population, suggesting utility early stratification.

Language: Английский

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Correlation between cardiometabolic index and psoriasis: a cross-sectional analysis using NHANES data

Frontiers in Physiology, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

Psoriasis is closely associated with metabolic health. The Cardiometabolic Index (CMI) an innovative and easily obtainable metric employed to assess cardiometabolic This study aims examine the possible relationship between CMI psoriasis. Data from four successive cycles of National Health Nutrition Examination Survey (NHANES) conducted 2003-2004 2009-2014 were employed. encompassed adults self-reported psoriasis diagnoses comprehensive information necessary for calculating CMI. calculation formula Triglycerides (TG)/High-density lipoprotein cholesterol (HDL-C) × WHtR (WHtR = waist circumference/height). A multivariable logistic regression model was utilized linear Subgroup analyses investigate potential contributing factors. further established using smooth curve fitting. study, utilizing NHANES data, comprised a cohort 7,327 American adults. analysis indicated that in fully adjusted model, people greatest had 71% increased probability relative those lowest (OR 1.71; 95% CI, 1.11-2.61, P < 0.05). Smooth fitting demonstrated connection (P subgroup revealed no significant interactions specific subgroups (all > Our research indicates substantial correlation method facilitates identification groups at risk psoriasis, therefore guiding therapeutic solutions public health activities improve dermatological outcomes.

Language: Английский

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Association between cardiometabolic index (CMI) and suicidal ideation: A cross-sectional analysis of NHANES 2005 to 2018 data

Medicine, Journal Year: 2025, Volume and Issue: 104(11), P. e41816 - e41816

Published: March 14, 2025

With suicide ranking as a leading cause of death globally, identifying modifiable risk factors is crucial. Suicidal ideation (SI) significant precursor to suicide, and there growing interest in the role cardiometabolic factors, particularly index (CMI), multiplying triglyceride-to-high-density lipoprotein cholesterol ratio by waist-to-height ratio, mental health outcomes. Previous studies have shown notable relationship among lipid abnormalities, elevated triglyceride levels, depressive symptom severity, including SI. This research investigated correlation between CMI levels adult Americans SI, utilizing data from National Health Nutrition Examination Survey (NHANES) ranging years 2005 2018. After collecting on demographics, physical examinations, laboratory testing, multivariate logistic regression analysis was conducted assess SI while adjusting for relevant factors. The study, which enrolled 15,849 individuals exhibiting symptoms constituting 3.47% total, revealed association A positive found (adjusted OR = 1.07, 95% CI: 1.02-1.13, P .0029). Moreover, nonlinear identified characterized an atypical inverted U-shaped curve with breakpoint at approximately 2.08. Subgroup consistent findings across various demographic clinical subpopulations. this study demonstrate substantial increased incidence within US population. Early interventions targeted such psychological support or lifestyle adjustments, may mitigate

Language: Английский

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L-shaped correlation between serum alpha-1-acid glycoprotein concentration and urinary albumin creatinine ratio in females: a cross-sectional survey

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 24, 2025

Background Alpha-1-acid glycoprotein (AGP) is a vital acute phase reactant that increases when glomerular filtration impaired, making it potential biomarker of kidney disease. The urine albumin-to-creatinine ratio (UACR) sensitive indicator proteinuria and frequently used to screen for disease in its early stage. aim this study was explore their correlation order advance our understanding the mechanisms underlying damage. Methods This included 2579 female participants with serum AGP UACR from National Health Nutrition Examination Survey (2015-2018). We divided all equally into three groups based on concentration. univariate multivariate regression models were assessing between UACR. Subgroup analyses then performed effect each covariate correlation. Smoothing splines utilized nonlinear identify thresholds within it. Results After adjusting models, significantly positively associated (p&lt;0.0001). identified specific cohort non-Hispanic Black individuals under 20 years age, characterized by BMI below 25 kg/m² waist circumference 80 cm or more. Within cohort, those hypertension sleep disorders but without hypercholesterolemia diabetes exhibited higher (p &lt; 0.001). Furthermore, we discovered an L-shaped concentration Specifically, less than 140 mg/dL, plateaued. Conclusions first address found threshold mg/dl. could be target intervention reduce risk

Language: Английский

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Association between cardiac metabolic index and diabetic kidney disease: a cross-sectional study of NHANES 1999–2018

Journal of Health Population and Nutrition, Journal Year: 2025, Volume and Issue: 44(1)

Published: April 3, 2025

Language: Английский

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Association between cardiometabolic index and infertility risk: a cross-sectional analysis of NHANES data (2013–2018)

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 2, 2025

The cardiometabolic index (CMI), a novel measure of obesity that integrates lipid profiles and indicators abdominal adiposity, has emerged as promising marker metabolic health. However, its relationship with infertility remains largely unexplored. Using data from the National Health Nutrition Examination Survey (NHANES) conducted between 2013 2018, this study investigated potential association CMI risk. We utilized weighted multivariate logistic regression to examine employed restricted cubic spline model explore non-linear relationships. Interaction tests subgroups analyses were assess heterogeneity across different subgroups. analysis included nationally representative cohort 1,142 women. After controlling for confounders, positive was identified risk (OR: 1.47; 95% CI: 1.05-2.06; p = 0.028). revealed (p 0.0109), an inflection point at value 0.341. Our findings provides evidence among U.S. adults. These results suggest could serve simple effective surrogate assessment, offering valuable insights reproductive health management.

Language: Английский

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Association of cardiometabolic index with gallstone disease and insulin resistance based on NHANES data

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 9, 2025

Language: Английский

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