Infarct-like myocarditis in adolescents: Exploring genetic insights from diagnosis through follow-up DOI Creative Commons
Roger Esmel-Vilomara, Lucía Riaza, Paola Dolader

et al.

International Journal of Cardiology, Journal Year: 2025, Volume and Issue: unknown, P. 133255 - 133255

Published: April 1, 2025

Myocarditis has traditionally been considered an acquired condition, but recent evidence suggests a genetic contribution, primarily in complicated cases. Data on pediatric uncomplicated or infarct-like myocarditis remain scarce. This study aimed to assess the prevalence of pathogenic likely (P/LP) variants adolescents with and their association clinical imaging findings. prospective, multicenter included 30 diagnosed across five hospitals Catalunya, Spain (2016-2024). Diagnosis was confirmed using 2018 Lake Louise Criteria cardiac magnetic resonance (CMR). Follow-up CMR performed at 12 months, testing conducted next-generation sequencing panel targeting 174 genes associated inherited diseases. P/LP cardiomyopathy-associated were identified 22.2 % patients. Baseline showed no significant differences ventricular function LGE extent, ring-like pattern significantly findings (p = 0.025), while septal involvement p-value 0.056. Over median follow-up 3 years (IQR 2-7), 9 patients (30 %) experienced recurrent myocarditis, more frequently genetic-positive (66.7 vs. 23.8 %). At exhibited greater burden 0.047) persistent myocardial edema T2-STIR 0.009), suggesting ongoing remodeling. The high highlights need for testing, particularly involvement. Persistent abnormalities symptomatic recurrences cases support long-term monitoring, even seemingly presentations.

Language: Английский

Infarct-like myocarditis in adolescents: Exploring genetic insights from diagnosis through follow-up DOI Creative Commons
Roger Esmel-Vilomara, Lucía Riaza, Paola Dolader

et al.

International Journal of Cardiology, Journal Year: 2025, Volume and Issue: unknown, P. 133255 - 133255

Published: April 1, 2025

Myocarditis has traditionally been considered an acquired condition, but recent evidence suggests a genetic contribution, primarily in complicated cases. Data on pediatric uncomplicated or infarct-like myocarditis remain scarce. This study aimed to assess the prevalence of pathogenic likely (P/LP) variants adolescents with and their association clinical imaging findings. prospective, multicenter included 30 diagnosed across five hospitals Catalunya, Spain (2016-2024). Diagnosis was confirmed using 2018 Lake Louise Criteria cardiac magnetic resonance (CMR). Follow-up CMR performed at 12 months, testing conducted next-generation sequencing panel targeting 174 genes associated inherited diseases. P/LP cardiomyopathy-associated were identified 22.2 % patients. Baseline showed no significant differences ventricular function LGE extent, ring-like pattern significantly findings (p = 0.025), while septal involvement p-value 0.056. Over median follow-up 3 years (IQR 2-7), 9 patients (30 %) experienced recurrent myocarditis, more frequently genetic-positive (66.7 vs. 23.8 %). At exhibited greater burden 0.047) persistent myocardial edema T2-STIR 0.009), suggesting ongoing remodeling. The high highlights need for testing, particularly involvement. Persistent abnormalities symptomatic recurrences cases support long-term monitoring, even seemingly presentations.

Language: Английский

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