Temporal Dynamics of Acute Coronary Syndromes During the COVID-19 Pandemic: A Retrospective Comparative Analysis Across Pre-Pandemic, Pandemic, and Post-Pandemic Phases
Acta Medica Nicomedia,
Journal Year:
2025,
Volume and Issue:
8(1), P. 45 - 51
Published: Feb. 28, 2025
Objective:
The
COVID-19
pandemic,
caused
by
SARS-CoV-2,
disrupted
global
healthcare
systems
and
significantly
influenced
cardiovascular
health.
This
study
examines
the
temporal
trends
of
acute
coronary
syndromes
(ACS),
including
ST-elevation
myocardial
infarction
(STEMI),
non-ST-elevation
(NSTEMI),
unstable
angina
pectoris
(USAP),
across
pre-pandemic,
post-pandemic
periods.
Methods:
retrospective
observational
was
conducted
at
a
single
tertiary
center
involving
patients
diagnosed
with
ACS
from
January
2018
to
June
2024.
Patients
were
stratified
into
three
cohorts:
pre-pandemic
(January
2018-February
2020),
pandemic
(March
2020-April
2022),
(May
2022-June
2024).
Results:
incidence
STEMI
NSTEMI
increased
in
period
compared
those
other
periods
(p
Language: Английский
The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging
Aging Cell,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 23, 2025
ABSTRACT
Human
aging
presents
an
evolutionary
paradox:
while
rates
remain
constant,
healthspan
and
lifespan
vary
widely.
We
address
this
conundrum
via
salutogenesis—the
active
production
of
health—through
immune
resilience
(IR),
the
capacity
to
resist
disease
despite
inflammation.
Analyzing
~17,500
individuals
across
stages
inflammatory
challenges,
we
identified
a
core
salutogenic
mechanism:
IR
centered
on
TCF7
,
conserved
transcription
factor
maintaining
T‐cell
stemness
regenerative
potential.
integrates
innate
adaptive
immunity
counter
three
mortality
drivers:
chronic
inflammation
(inflammaging),
aging,
cellular
senescence.
By
mitigating
these
mechanisms,
confers
survival
advantages:
At
age
40,
with
poor
face
9.7‐fold
higher
rate—a
risk
equivalent
that
55.5‐year‐olds
optimal
IR—resulting
in
15.5‐year
gap
survival.
Optimal
preserves
youthful
profiles
at
any
age,
enhances
vaccine
responses,
reduces
burdens
cardiovascular
disease,
Alzheimer's,
serious
infections.
Two
key
themes
emerge:
first,
female‐predominant
IR,
including
likely
reflects
pressures
favoring
reproductive
success
caregiving;
second,
midlife
(40–70
years)
is
critical
window
where
by
69%.
After
70,
converge
between
resilient
non‐resilient
groups,
reflecting
biological
limits
longevity
extension.
TNFα‐blockers
restore
salutogenesis
pathways,
indicating
delays
aging‐related
processes
rather
than
altering
rates.
reframing
as
salutogenic‐pathogenic
balance,
establish
‐centered
central
healthy
longevity.
Targeted
interventions
enhance
offer
actionable
strategies
maximize
before
constraints
limit
benefits.
Language: Английский
Assessment of Post-COVID-19 Functional Status and Complications Among Survivors at a Tertiary Healthcare Center in Bangladesh
Cureus,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 23, 2025
Language: Английский
Are Pre‐Hospitalization ECG Abnormalities Associated With Increased Mortality in COVID‐19 Patients? A Quantitative Systematic Literature Review
Annals of Noninvasive Electrocardiology,
Journal Year:
2024,
Volume and Issue:
29(6)
Published: Oct. 12, 2024
ABSTRACT
Background
While
COVID‐19
is
predominantly
a
respiratory
disease,
cardiovascular
complications
occur
and
are
associated
with
worse
outcomes.
Electrocardiogram
(ECG)
abnormalities
frequently
observed
in
hospitalized
patients,
some
of
which
increased
mortality.
It
unclear
whether
ECG
occurring
before
hospitalization
This
quantitative
systematic
literature
review
aims
to
determine
changes
mortality
discuss
these
findings
can
aid
the
assessment
patients
decision‐making
pre‐hospital
environment.
Methods
A
search
following
digital
databases
was
conducted:
CINAL,
PUBMED,
MEDLINE,
Coronavirus
Research
Database.
Eight
cohort
studies
(primary
papers)
including
ECGs
taken
Emergency
Department
were
selected
for
synthesis
results
obtained
prevalence
among
survivors
compared
non‐survivors.
Odds
hazard
ratios
also
collected
compared.
Results
Identification
on
pre‐hospitalization
patients.
These
include
non‐sinus
rhythm,
QTc
prolongation,
left
bundle
branch
block,
axis
deviation,
atrial
fibrillation,
flutter,
right
ventricular
strain
patterns,
ST
segment
changes,
T
wave
abnormalities,
evidence
hypertrophy.
Conclusion
environment
may
be
beneficial
when
assessing
could
help
identify
at
risk
Language: Английский
Comparison of different T cell assays for the retrospective determination of SARS-CoV-2 infection
Journal of General Virology,
Journal Year:
2024,
Volume and Issue:
105(12)
Published: Dec. 20, 2024
It
is
important
to
be
able
retrospectively
determine
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infections
with
high
accuracy,
both
for
post-coronavirus
disease
2019
(COVID-19)
epidemiological
studies,
and
distinguish
between
Long
COVID
other
multi-syndromic
diseases
that
have
overlapping
symptoms.
Although
serum
antibody
levels
can
measured
diagnose
SARS-CoV-2
infections,
peptide
stimulation
of
memory
T
cell
responses
a
more
sensitive
approach.
This
because
robust
cells
are
generated
after
infection
persist
even
antibodies
wane
below
detectability
thresholds.
In
this
study,
we
compare
using
FluoroSpot-based
methods
overnight
whole
blood
peptides
followed
by
an
ELISA.
Both
approaches
comparable
sensitivity
specificity
but
require
different
equipment
samples
used.
Furthermore,
the
elimination
cross-react
coronaviruses
increases
assay
trades
off
some
sensitivity.
Finally,
approach
used
on
archival,
cryopreserved
PBMCs.
work
shows
comparative
advantages
several
measure
could
utilized
any
laboratory
studying
effects
pandemic.
Language: Английский