Role of right dorsolateral prefrontal cortex–left primary motor cortex interaction in motor inhibition in Parkinson’s disease DOI Creative Commons
Zhen Wang, Jianing Wei, Yuyu Song

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 5, 2025

Impaired motor inhibition in Parkinson's disease (PD) is associated with functional alterations the frontal-basal ganglia (BG) neural circuits. The right dorsolateral prefrontal cortex (DLPFC), pre-supplementary area (pre-SMA), and primary (M1) play key roles regulating this inhibition. However, changes interhemispheric interactions during PD have not been clearly defined. We used dual-site paired-pulse transcranial magnetic stimulation (ppTMS) to examine between DLPFC pre-SMA left M1 30 patients early-stage age-matched healthy controls (HC) both resting active conditions, specifically while performing a stop-signal task (SST). Stop-signal reaction times (SSRT) were significantly longer compared HC. DLPFC-left interaction, at short- long-latency intervals, showed enhanced following stop-signal. In patients, SSRT was correlated of stronger shorter SSRT. deficit reactive observed linked an abnormal modulation interaction stopping process.

Language: Английский

Role of right dorsolateral prefrontal cortex–left primary motor cortex interaction in motor inhibition in Parkinson’s disease DOI Creative Commons
Zhen Wang, Jianing Wei, Yuyu Song

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 5, 2025

Impaired motor inhibition in Parkinson's disease (PD) is associated with functional alterations the frontal-basal ganglia (BG) neural circuits. The right dorsolateral prefrontal cortex (DLPFC), pre-supplementary area (pre-SMA), and primary (M1) play key roles regulating this inhibition. However, changes interhemispheric interactions during PD have not been clearly defined. We used dual-site paired-pulse transcranial magnetic stimulation (ppTMS) to examine between DLPFC pre-SMA left M1 30 patients early-stage age-matched healthy controls (HC) both resting active conditions, specifically while performing a stop-signal task (SST). Stop-signal reaction times (SSRT) were significantly longer compared HC. DLPFC-left interaction, at short- long-latency intervals, showed enhanced following stop-signal. In patients, SSRT was correlated of stronger shorter SSRT. deficit reactive observed linked an abnormal modulation interaction stopping process.

Language: Английский

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