The combined effects of cardiometabolic index and high-sensitivity C-reactive protein on the risk of new onset stroke in a Chinese national prospective longitudinal cohort study

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 8, 2025

The Cardiometabolic Index (CMI) represents a novel anthropometric measurement, which combines characteristics of adiposity and lipids. Since obesity, lipid metabolism, inflammation may collectively facilitate the occurrence stroke, we hypothesize that combination elevated levels CMI high-sensitivity C-reactive protein (hs-CRP) increases risk future stroke among middle-aged older Chinese adults. This study included 8,973 participants aged 45 years or from China Longitudinal Study on Health Retirement (CHARLS), who were stroke-free underwent baseline evaluations between 2011 2012, with followed-up at 2013, 2015 2018. exposures hs-CRP, calculated using formula [waist circumference (cm)/height (cm)] × [triglycerides (mmol/L)/HDL-C (mmol/L)]. primary outcome was new-onset events. Cox proportional hazards models restricted cubic spline (RCS) analyses conducted to examine associations CMI, their combined effects risk. Sensitivity analysis further implemented verify robustness results. A total 629 (7.01%) suffered during follow-up. for increased each elevating quartile levels, adjusted HRs 95% CIs being 1.27 (0.98–1.66), 1.41 (1.08–1.83), 1.46 (1.09–1.96) Q2, Q3, Q4, respectively. Moreover, hs-CRP ≥ 2 mg/L also had significantly higher incidence compared those CRP < (adjusted HR 1.24, CI 1.05–1.47, p = 0.012). Specifically, concurrently highest 1.90, 1.32–2.74). subsequent sensitivity yielded consistent results, corroborating initial findings. exhibited significant association adults, highlighting importance joint assessments these biomarkers refining stratification enhancing prevention strategies stroke.

Language: Английский

---

Exercise Training and Cardiac Rehabilitation in Patients After Percutaneous Coronary Intervention: Comprehensive Assessment and Prescription

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1607 - 1607

Published: Feb. 27, 2025

Current guidelines on acute and chronic coronary syndromes recommend comprehensive multidisciplinary exercise-based cardiac rehabilitation in Class I. Indeed, patients after a percutaneous intervention, this supervised structured program improves cardiovascular risk reduces adverse events mortality. After an initial assessment, including peak exercise capacity evaluation, follow tailored consisting of aerobic resistance training, factor management, dietary counselling, physical activity weight control psychosocial support, education. However, management prescription require careful assessment consideration several variables such as left ventricular dysfunction, comorbidities, aging, artery disease severity, capacity, type syndrome. The functional prognostic benefits have been widely demonstrated intervention; however, referral is still limited, although should be strongly recommended to these the context prevention. Therefore, aim our article provide updated, critical, state-of-the-art review training programs intervention. Furthermore, practical approaches with personalized intervention will provided.

Language: Английский

---

Beneath the Surface: The Emerging Role of Ultra-Processed Foods in Obesity-Related Cancer

Current Oncology Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Abstract Purposeof Review Ultra-processed foods (UPFs) are becoming more and important in daily diets around the world; some cases, they can account for as much 60% of energy intake. Epidemiological evidence suggests that this shift toward high levels food processing may be partially responsible global obesity epidemic rise prevalence chronic diseases. Recent Findings Few prospective studies have examined relationship between UPF consumption cancer outcomes. According to currently available information, UPFs increase risk due their obesogenic properties exposure substances cause cancer, such certain additives pollution from product processing. The complex involves factors immune dysregulation, altered adipokine sex hormone levels, abnormal fatty acid metabolism, extracellular matrix remodeling, inflammation. Addressing associated with could involve a multifaceted approach, including consumer behavior modification programs robust public health regulations aimed at enhancing environments. Improved knowledge potential dual negative impacts on environment is one priority areas we identify future research policy implications. Various approaches used prevent cancers consumption, change stricter needed improve environment. Summary This review examines first time role obesity, exploring underlying biological mechanisms identifying key action, environmental impact UPFs.

Language: Английский

---

Cardiovascular disease risk assessment, exercise training, and management of complications in patients with chronic kidney disease

International Journal of Cardiology Cardiovascular Risk and Prevention, Journal Year: 2025, Volume and Issue: 25, P. 200386 - 200386

Published: March 6, 2025

Patients with chronic kidney disease are at high and very risk of cardiovascular disease. As estimated glomerular filtration rate declines, the incidence severity factors, complications, atherosclerotic events increase. In this scenario, tailored assessment is key to evaluate estimate risk. Personalized stratification differentiates patients without diabetes mellitus or established in their management beneficial treatment. Exercise intensity prescription suggested propose specific safe recommendations for physical activity, training, cardiac rehabilitation. Programs based on a combination endurance resistance exercise should be adapted haemodialysis after transplantation. Appropriate complications these patients, such as heart failure, arrhythmias, coronary artery disease, essential ensure best treatment improve prognosis. Therefore, we critical comprehensive review suggest how manage clinical practice and, specifically, regard assessment, training prescription, complications.

Language: Английский

---

Adverse effects with tirzepatide: a protocol for a systematic review with meta-analysis and Trial Sequential Analysis

BMJ Open, Journal Year: 2025, Volume and Issue: 15(4), P. e094947 - e094947

Published: April 1, 2025

Introduction Cardiovascular diseases remain the leading cause of mortality worldwide. Tirzepatide is approved for treatment type 2 diabetes mellitus and overweight increasingly used. The adverse effects with tirzepatide may not be disease-specific have been assessed previously. Methods analysis We will conduct a systematic review search major medical databases (Cochrane Central Register Controlled Trials, Medical Literature Analysis Retrieval System Online (MEDLINE), Excerpta Medica database (EMBASE), Latin American Caribbean Health Sciences (LILACS), Science Citation Index Expanded (SCI-EXPANDED), Conference Proceedings Index—Science (CPCI-S)) clinical trial registries from their inception onwards to identify relevant randomised trials. expect literature in January 2025. Two authors independently extract data perform risk bias assessments. include trials comparing versus placebo or no intervention all patient groups an increased cardiovascular events. Primary outcomes all-cause serious Secondary myocardial infarction, stroke, hospitalisation non-serious Data synthesised by meta-analyses Trial Sequential Analysis, Cochrane Risk Bias tool—version 2. systematically assess if thresholds statistical significance are crossed, certainty evidence Grading Recommendations, Assessment, Development Evaluations. Ethics dissemination This protocol does present any results. Findings this published international peer-reviewed scientific journals. PROSPERO registration number CRD42024599035.

Language: Английский

---

Obesity in the Philippines: Addressing Cardiovascular Risks Through Healthy Lifestyle

International Journal of Cardiology Cardiovascular Risk and Prevention, Journal Year: 2025, Volume and Issue: 25, P. 200408 - 200408

Published: April 17, 2025

Language: Английский

---

Liver steatosis is positively associated with plasminogen activator inhibitor-1 in apparently healthy individuals with overweight and obesity: A FibroScan-Based Cross-Sectional study

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 29, 2025

Language: Английский

---

Epicardial Fat Volume Assessed by MRI in Adolescents: Associations with Obesity and Cardiovascular Risk Factors

Journal of Cardiovascular Development and Disease, Journal Year: 2024, Volume and Issue: 11(12), P. 383 - 383

Published: Nov. 29, 2024

Background: In adults, epicardial adipose tissue (EAT) is associated with metabolic syndrome (MS) and coronary artery disease. EAT thickness increased in obese youth, but total volume its correlation cardiovascular risk factors have not been studied. Objectives: To determine adolescents association obesity factors. Methods: We performed a cross-sectional study including 48 pubertal (24 24 lean subjects, aged 13.6 ± 1.5 yr). as well visceral subcutaneous abdominal volumes were obtained by magnetic resonance imaging. Anthropometrical parameters; blood pressure (BP); fasting serum triglycerides; low- high-density lipoprotein (HDL-C) cholesterol; glucose; insulin levels measured. Results: Obese had higher compared to controls (49.6 18.0 vs. 17.6 6.7 cm3, p < 0.0005). They also significantly fat volumes, systolic BP, triglycerides, levels, decreased HDL-C concentration. was anthropometrical indices factors: waist circumference, resistance indices. Metabolic present 25% of adolescents. MS those without (63.5 21.4 44.9 14.6 = 0.026). Conclusions: volume, which known contribute atherogenesis adolescents, fat, factors, MS. Excessive early life may the development premature cardiometabolic

Language: Английский

---

Systemic Inflammation and Oxidative Stress in Childhood Obesity: Sex Differences in Adiposity Indices and Cardiovascular Risk

Biomedicines, Journal Year: 2024, Volume and Issue: 13(1), P. 58 - 58

Published: Dec. 29, 2024

Background: Systemic inflammation and oxidative stress are fundamental contributors to the onset of conditions related childhood obesity, such as cardiovascular (CV) diseases. We aimed assess CV risk in obesity by examining sex differences adiposity indices, cardiometabolic profiles, inflammation, biomarkers. also potential interferon-inducible T-cell alpha chemoattractant (I-TAC/CXCL11) a novel biomarker. Methods: Eighty children (36 girls) aged 5-18 years with overweight, or normal weight were analyzed. Fasting blood samples obtained C-reactive protein (CRP), leukocytes, myeloperoxidase (MPO), adiponectin, monocyte protein-1, superoxide dismutase-1, I-TAC/CXCL11, comprehensive profile, including glucose, lipid, renal, liver, thyroid function markers. Adiposity indices determined using bioelectrical impedance analysis (BIA) anthropometric measures, BMI, waist-to-hip waist-to-height ratios, visceral subcutaneous fat thickness. Blood pressure (BP) pulse wave velocity evaluated. Results: Girls had less central fewer factors than boys, despite having similar total mass. Both girls boys overweight showed higher CRP levels. excess increased leukocyte counts, while elevated MPO levels, which correlated positively systolic BP, homocysteine, negatively HDL. I-TAC/CXCL11 levels across groups. Conclusions: essential for evaluating adolescents, underscoring need tailored approaches. significantly markers, supporting its inclusion routine assessments. warrants further study obesity.

Language: Английский

---